ADORA2B

adenosine A2b receptor

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2, Li-Fraumeni Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

GO terms:

Biological Process:
activation of MAPK activity [GO:0000187],
adenosine receptor signaling pathway [GO:0001973],
positive regulation of chronic inflammatory response to non-antigenic stimulus [GO:0002882],
cellular defense response [GO:0006968],
G-protein coupled receptor signaling pathway [GO:0007186],
adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189],
activation of adenylate cyclase activity [GO:0007190],
JNK cascade [GO:0007254],
excretion [GO:0007588],
positive regulation of vascular endothelial growth factor production [GO:0010575],
positive regulation of cGMP-mediated signaling [GO:0010753],
positive regulation of guanylate cyclase activity [GO:0031284],
cellular response to extracellular stimulus [GO:0031668],
positive regulation of chemokine production [GO:0032722],
positive regulation of interleukin-6 production [GO:0032755],
positive regulation of mast cell degranulation [GO:0043306],
cellular protein metabolic process [GO:0044267],
relaxation of vascular smooth muscle [GO:0060087],
regulation of synaptic vesicle exocytosis [GO:2000300],
positive regulation of endothelial cell proliferation [GO:0001938],
signal transduction [GO:0007165],
positive regulation of cell proliferation [GO:0008284],
negative regulation of cell proliferation [GO:0008285],
positive regulation of endothelial cell migration [GO:0010595],
positive regulation of norepinephrine secretion [GO:0010701],
positive regulation of steroid biosynthetic process [GO:0010893],
regulation of glucose metabolic process [GO:0010906],
negative regulation of collagen biosynthetic process [GO:0032966],
positive regulation of catecholamine secretion [GO:0033605],
positive regulation of cAMP-mediated signaling [GO:0043950],
response to angiotensin [GO:1990776],
positive regulation of interleukin-6 secretion [GO:2000778],

Molecular Function:
G-protein coupled adenosine receptor activity [GO:0001609],
protein binding [GO:0005515],
G-protein coupled receptor activity [GO:0004930],

Cellular Component:
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
glutamatergic synapse [GO:0098978],
cell surface [GO:0009986],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
synapse [GO:0045202],