ADORA1

adenosine A1 receptor

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
activation of MAPKK activity [GO:0000186],
temperature homeostasis [GO:0001659],
response to hypoxia [GO:0001666],
adenosine receptor signaling pathway [GO:0001973],
regulation of respiratory gaseous exchange by neurological system process [GO:0002087],
negative regulation of acute inflammatory response [GO:0002674],
negative regulation of leukocyte migration [GO:0002686],
positive regulation of peptide secretion [GO:0002793],
positive regulation of systemic arterial blood pressure [GO:0003084],
negative regulation of systemic arterial blood pressure [GO:0003085],
regulation of glomerular filtration [GO:0003093],
protein targeting to membrane [GO:0006612],
phagocytosis [GO:0006909],
inflammatory response [GO:0006954],
signal transduction [GO:0007165],
G-protein coupled receptor signaling pathway [GO:0007186],
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [GO:0007193],
cell-cell signaling [GO:0007267],
nervous system development [GO:0007399],
negative regulation of cell proliferation [GO:0008285],
negative regulation of glutamate secretion [GO:0014050],
lipid catabolic process [GO:0016042],
negative regulation of synaptic transmission, GABAergic [GO:0032229],
positive regulation of nucleoside transport [GO:0032244],
negative regulation of neurotrophin production [GO:0032900],
positive regulation of protein dephosphorylation [GO:0035307],
negative regulation of renal sodium excretion [GO:0035814],
negative regulation of circadian sleep/wake cycle, non-REM sleep [GO:0042323],
negative regulation of apoptotic process [GO:0043066],
positive regulation of potassium ion transport [GO:0043268],
positive regulation of epidermal growth factor-activated receptor activity [GO:0045741],
negative regulation of heart contraction [GO:0045822],
negative regulation of hormone secretion [GO:0046888],
cognition [GO:0050890],
detection of temperature stimulus involved in sensory perception of pain [GO:0050965],
negative regulation of lipid catabolic process [GO:0050995],
positive regulation of lipid catabolic process [GO:0050996],
regulation of sensory perception of pain [GO:0051930],
negative regulation of synaptic transmission, glutamatergic [GO:0051967],
fatty acid homeostasis [GO:0055089],
excitatory postsynaptic potential [GO:0060079],
relaxation of vascular smooth muscle [GO:0060087],
negative regulation of mucus secretion [GO:0070256],
triglyceride homeostasis [GO:0070328],
regulation of cardiac muscle cell contraction [GO:0086004],
apoptotic signaling pathway [GO:0097190],
regulation of presynaptic cytosolic calcium ion concentration [GO:0099509],
negative regulation of long-term synaptic potentiation [GO:1900272],
negative regulation of long term synaptic depression [GO:1900453],
positive regulation of neuron death [GO:1901216],
negative regulation of circadian sleep/wake cycle, sleep [GO:0042321],
negative regulation of blood pressure [GO:0045776],
positive regulation of blood pressure [GO:0045777],
negative regulation of inflammatory response [GO:0050728],
regulation of cardiac muscle contraction [GO:0055117],

Molecular Function:
G-protein coupled adenosine receptor activity [GO:0001609],
G-protein coupled receptor binding [GO:0001664],
purine nucleoside binding [GO:0001883],
protein binding [GO:0005515],
heat shock protein binding [GO:0031072],
G-protein beta/gamma-subunit complex binding [GO:0031683],
heterotrimeric G-protein binding [GO:0032795],
protein heterodimerization activity [GO:0046982],
neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration [GO:0099582],
G-protein coupled receptor activity [GO:0004930],
macromolecular complex binding [GO:0044877],

Cellular Component:
endoplasmic reticulum [GO:0005783],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
postsynaptic density [GO:0014069],
basolateral plasma membrane [GO:0016323],
axolemma [GO:0030673],
neuronal cell body [GO:0043025],
terminal bouton [GO:0043195],
dendritic spine [GO:0043197],
calyx of Held [GO:0044305],
presynaptic active zone [GO:0048786],
integral component of postsynaptic membrane [GO:0099055],
integral component of presynaptic membrane [GO:0099056],
endomembrane system [GO:0012505],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
dendrite [GO:0030425],
asymmetric synapse [GO:0032279],
presynaptic membrane [GO:0042734],
cell body [GO:0044297],
synapse [GO:0045202],
postsynaptic membrane [GO:0045211],