ADM

adrenomedullin

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
30987592 MCF7 Breast Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES
31983656 MSC Human YES

GO terms:

Biological Process:
vasculogenesis [GO:0001570],
response to hypoxia [GO:0001666],
neural tube closure [GO:0001843],
regulation of the force of heart contraction [GO:0002026],
G-protein coupled receptor internalization [GO:0002031],
regulation of systemic arterial blood pressure [GO:0003073],
inflammatory response [GO:0006954],
signal transduction [GO:0007165],
G-protein coupled receptor signaling pathway [GO:0007186],
adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189],
positive regulation of cytosolic calcium ion concentration [GO:0007204],
heart development [GO:0007507],
female pregnancy [GO:0007565],
aging [GO:0007568],
androgen metabolic process [GO:0008209],
positive regulation of cell proliferation [GO:0008284],
negative regulation of cell proliferation [GO:0008285],
response to cold [GO:0009409],
response to wounding [GO:0009611],
positive regulation of heart rate [GO:0010460],
animal organ regeneration [GO:0031100],
neuron projection regeneration [GO:0031102],
receptor internalization [GO:0031623],
response to lipopolysaccharide [GO:0032496],
response to insulin [GO:0032868],
regulation of urine volume [GO:0035809],
odontogenesis of dentin-containing tooth [GO:0042475],
response to starvation [GO:0042594],
positive regulation of apoptotic process [GO:0043065],
negative regulation of vascular permeability [GO:0043116],
positive regulation of angiogenesis [GO:0045766],
negative regulation of vasoconstriction [GO:0045906],
hormone secretion [GO:0046879],
developmental growth [GO:0048589],
response to glucocorticoid [GO:0051384],
branching involved in labyrinthine layer morphogenesis [GO:0060670],
vascular smooth muscle cell development [GO:0097084],
amylin receptor signaling pathway [GO:0097647],
adrenomedullin receptor signaling pathway [GO:1990410],
positive regulation of progesterone biosynthetic process [GO:2000184],
positive regulation of vasculogenesis [GO:2001214],
antibacterial humoral response [GO:0019731],
defense response to Gram-negative bacterium [GO:0050829],
defense response to Gram-positive bacterium [GO:0050830],
calcium ion homeostasis [GO:0055074],
spongiotrophoblast layer development [GO:0060712],

Molecular Function:
receptor binding [GO:0005102],
hormone activity [GO:0005179],
adrenomedullin receptor binding [GO:0031700],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
cytoplasm [GO:0005737],