CLTC

clathrin heavy chain

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

GO terms:

Biological Process:
mitotic cell cycle [GO:0000278],
osteoblast differentiation [GO:0001649],
intracellular protein transport [GO:0006886],
receptor-mediated endocytosis [GO:0006898],
autophagy [GO:0006914],
antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886],
receptor internalization [GO:0031623],
low-density lipoprotein particle receptor catabolic process [GO:0032802],
transferrin transport [GO:0033572],
low-density lipoprotein particle clearance [GO:0034383],
retrograde transport, endosome to Golgi [GO:0042147],
clathrin coat assembly [GO:0048268],
cell division [GO:0051301],
Wnt signaling pathway, planar cell polarity pathway [GO:0060071],
regulation of mitotic spindle organization [GO:0060236],
membrane organization [GO:0061024],
clathrin-dependent endocytosis [GO:0072583],
negative regulation of hyaluronan biosynthetic process [GO:1900126],
negative regulation of protein localization to plasma membrane [GO:1903077],
Golgi organization [GO:0007030],
cell cycle [GO:0007049],
vesicle-mediated transport [GO:0016192],
synaptic vesicle endocytosis [GO:0048488],
mitotic spindle assembly [GO:0090307],

Molecular Function:
RNA binding [GO:0003723],
double-stranded RNA binding [GO:0003725],
structural molecule activity [GO:0005198],
protein binding [GO:0005515],
protein kinase binding [GO:0019901],
clathrin light chain binding [GO:0032051],
low-density lipoprotein particle receptor binding [GO:0050750],
disordered domain specific binding [GO:0097718],
ubiquitin-specific protease binding [GO:1990381],
protein C-terminus binding [GO:0008022],
ankyrin binding [GO:0030506],
heat shock protein binding [GO:0031072],
peptide binding [GO:0042277],

Cellular Component:
lysosome [GO:0005764],
endosome [GO:0005768],
spindle [GO:0005819],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
focal adhesion [GO:0005925],
membrane [GO:0016020],
clathrin coat [GO:0030118],
clathrin coat of trans-Golgi network vesicle [GO:0030130],
clathrin coat of coated pit [GO:0030132],
clathrin-coated vesicle [GO:0030136],
clathrin-coated endocytic vesicle membrane [GO:0030669],
trans-Golgi network membrane [GO:0032588],
macromolecular complex [GO:0032991],
endolysosome membrane [GO:0036020],
melanosome [GO:0042470],
clathrin-coated endocytic vesicle [GO:0045334],
extracellular exosome [GO:0070062],
clathrin complex [GO:0071439],
mitotic spindle [GO:0072686],
extracellular vesicle [GO:1903561],
mitotic spindle microtubule [GO:1990498],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
cytoskeleton [GO:0005856],
clathrin-coated pit [GO:0005905],
membrane coat [GO:0030117],
T-tubule [GO:0030315],
cytoplasmic vesicle [GO:0031410],
Myb complex [GO:0031523],
sarcolemma [GO:0042383],
myelin sheath [GO:0043209],
presynaptic endocytic zone membrane [GO:0098835],
extrinsic component of synaptic vesicle membrane [GO:0098850],