CLCA2

chloride channel accessory 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30988157 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
proteolysis [GO:0006508],
cell adhesion [GO:0007155],
ion transmembrane transport [GO:0034220],
chloride transmembrane transport [GO:1902476],
ion transport [GO:0006811],
chloride transport [GO:0006821],

Molecular Function:
intracellular calcium activated chloride channel activity [GO:0005229],
chloride channel activity [GO:0005254],
metallopeptidase activity [GO:0008237],
ligand-gated ion channel activity [GO:0015276],
metal ion binding [GO:0046872],
peptidase activity [GO:0008233],
hydrolase activity [GO:0016787],

Cellular Component:
extracellular region [GO:0005576],
nucleoplasm [GO:0005654],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
basal plasma membrane [GO:0009925],
cell junction [GO:0030054],
nuclear membrane [GO:0031965],
membrane [GO:0016020],
integral component of membrane [GO:0016021],