CISD2

CDGSH iron sulfur domain 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
mitophagy [GO:0000422],
autophagy [GO:0006914],
multicellular organism aging [GO:0010259],
regulation of autophagy [GO:0010506],

Molecular Function:
protein homodimerization activity [GO:0042803],
metal ion binding [GO:0046872],
iron-sulfur cluster binding [GO:0051536],
2 iron, 2 sulfur cluster binding [GO:0051537],
RNA binding [GO:0003723],
protein binding [GO:0005515],

Cellular Component:
mitochondrion [GO:0005739],
mitochondrial outer membrane [GO:0005741],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
macromolecular complex [GO:0032991],
intracellular membrane-bounded organelle [GO:0043231],
perinuclear region of cytoplasm [GO:0048471],
perinuclear endoplasmic reticulum [GO:0097038],