CIB1

calcium and integrin binding 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
angiogenesis [GO:0001525],
negative regulation of protein phosphorylation [GO:0001933],
positive regulation of protein phosphorylation [GO:0001934],
positive regulation of cell-matrix adhesion [GO:0001954],
response to ischemia [GO:0002931],
double-strand break repair [GO:0006302],
apoptotic process [GO:0006915],
cellular response to DNA damage stimulus [GO:0006974],
negative regulation of microtubule depolymerization [GO:0007026],
endomitotic cell cycle [GO:0007113],
cell adhesion [GO:0007155],
spermatid development [GO:0007286],
positive regulation of cell proliferation [GO:0008284],
negative regulation of cell proliferation [GO:0008285],
negative regulation of neuron projection development [GO:0010977],
platelet formation [GO:0030220],
positive regulation of cell growth [GO:0030307],
positive regulation of cell migration [GO:0030335],
cytoplasmic microtubule organization [GO:0031122],
positive regulation of cell adhesion mediated by integrin [GO:0033630],
thrombopoietin-mediated signaling pathway [GO:0038163],
regulation of cell proliferation [GO:0042127],
negative regulation of apoptotic process [GO:0043066],
positive regulation of catalytic activity [GO:0043085],
negative regulation of megakaryocyte differentiation [GO:0045653],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
cell division [GO:0051301],
regulation of cell division [GO:0051302],
negative regulation of protein kinase B signaling [GO:0051898],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
positive regulation of calcineurin-NFAT signaling cascade [GO:0070886],
cellular response to tumor necrosis factor [GO:0071356],
cellular response to growth factor stimulus [GO:0071363],
negative regulation of protein serine/threonine kinase activity [GO:0071901],
positive regulation of protein serine/threonine kinase activity [GO:0071902],
positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050],
positive regulation of protein targeting to membrane [GO:0090314],
extrinsic apoptotic signaling pathway [GO:0097191],
positive regulation of substrate adhesion-dependent cell spreading [GO:1900026],
positive regulation of protein localization to plasma membrane [GO:1903078],
cellular response to nerve growth factor stimulus [GO:1990090],
positive regulation of male germ cell proliferation [GO:2000256],
cell cycle [GO:0007049],
spermatogenesis [GO:0007283],
cell differentiation [GO:0030154],

Molecular Function:
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
protein C-terminus binding [GO:0008022],
calcium-dependent protein kinase inhibitor activity [GO:0008427],
Ras GTPase binding [GO:0017016],
protein kinase binding [GO:0019901],
protein serine/threonine kinase inhibitor activity [GO:0030291],
protein anchor [GO:0043495],
ion channel binding [GO:0044325],
metal ion binding [GO:0046872],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
endoplasmic reticulum [GO:0005783],
Golgi apparatus [GO:0005794],
centrosome [GO:0005813],
plasma membrane [GO:0005886],
membrane [GO:0016020],
apical plasma membrane [GO:0016324],
lamellipodium [GO:0030027],
dendrite [GO:0030425],
growth cone [GO:0030426],
vesicle [GO:0031982],
filopodium tip [GO:0032433],
ruffle membrane [GO:0032587],
sarcolemma [GO:0042383],
neuron projection [GO:0043005],
neuronal cell body [GO:0043025],
perikaryon [GO:0043204],
perinuclear region of cytoplasm [GO:0048471],
extracellular exosome [GO:0070062],
cell periphery [GO:0071944],
cytoskeleton [GO:0005856],
axon [GO:0030424],
cell projection [GO:0042995],