CHEK2

checkpoint kinase 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
15192702 HFF, IMR-90 Human NO
16317088 A549, HaCaT Human NO
17136094 BJ, HMEC Human NO
20577265 MEF Mouse NO
23180582 Hs294T and SK-Mel-28 cells Human NO
28498365 PC-3, MDA-MB-231, PANC-1, DU 145 Human, mouse NO
30693443 Cochlea Mouse NO
31186408 OV-90,OV-1369,OV-4453,OV-1946,MDA-MB-231 Ovary, breast Human,Mouse
31635050 MCF-7 Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES
30987592 MCF7 Breast Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
DNA damage checkpoint [GO:0000077],
G2/M transition of mitotic cell cycle [GO:0000086],
replicative cell aging [GO:0001302],
positive regulation of protein phosphorylation [GO:0001934],
double-strand break repair [GO:0006302],
regulation of transcription, DNA-templated [GO:0006355],
protein phosphorylation [GO:0006468],
cellular response to DNA damage stimulus [GO:0006974],
DNA damage induced protein phosphorylation [GO:0006975],
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977],
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978],
intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630],
peptidyl-serine phosphorylation [GO:0018105],
regulation of protein catabolic process [GO:0042176],
signal transduction in response to DNA damage [GO:0042770],
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771],
cellular protein catabolic process [GO:0044257],
mitotic DNA damage checkpoint [GO:0044773],
positive regulation of transcription, DNA-templated [GO:0045893],
protein autophosphorylation [GO:0046777],
protein stabilization [GO:0050821],
cell division [GO:0051301],
negative regulation of cell cycle arrest [GO:0071157],
cellular response to gamma radiation [GO:0071480],
signal transduction involved in intra-S DNA damage checkpoint [GO:0072428],
mitotic spindle assembly [GO:0090307],
replicative senescence [GO:0090399],
regulation of signal transduction by p53 class mediator [GO:1901796],
response to glycoside [GO:1903416],
cellular response to bisphenol A [GO:1903926],
negative regulation of DNA damage checkpoint [GO:2000002],
positive regulation of anoikis [GO:2000210],
mitotic G2 phase [GO:0000085],
DNA repair [GO:0006281],
apoptotic process [GO:0006915],
cell cycle [GO:0007049],
response to gamma radiation [GO:0010332],
phosphorylation [GO:0016310],

Molecular Function:
protein serine/threonine kinase activity [GO:0004674],
protein binding [GO:0005515],
ATP binding [GO:0005524],
kinase activity [GO:0016301],
protein kinase binding [GO:0019901],
ubiquitin protein ligase binding [GO:0031625],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
metal ion binding [GO:0046872],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
transferase activity [GO:0016740],

Cellular Component:
chromosome, telomeric region [GO:0000781],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
Golgi apparatus [GO:0005794],
PML body [GO:0016605],