CHAF1B

chromatin assembly factor 1 subunit B

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29449545 HMEC, MRC5, IMR-90, GP293, WI-38, HUVEC Human NO
30987592 MCF7 Breast Human YES
30988157 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
DNA replication [GO:0006260],
DNA repair [GO:0006281],
nucleosome assembly [GO:0006334],
DNA replication-dependent nucleosome assembly [GO:0006335],
cell cycle [GO:0007049],
chromatin assembly [GO:0031497],
cellular response to DNA damage stimulus [GO:0006974],

Molecular Function:
chromatin binding [GO:0003682],
protein binding [GO:0005515],
histone binding [GO:0042393],
unfolded protein binding [GO:0051082],

Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
macromolecular complex [GO:0032991],
CAF-1 complex [GO:0033186],