CGAS

cyclic GMP-AMP synthase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28533362 BJ, MEF, B16F1 Human, mouse NO
28759028 MEF Mouse NO
29548335 Saos-2 Human YES
29622565 MEF Mouse NO
31183403 IMR-90 Human YES
32047109 NIH/3T3 Mouse NO
32075966 OVCAR-3 Human NO

GO terms:

Biological Process:
activation of innate immune response [GO:0002218],
positive regulation of defense response to virus by host [GO:0002230],
regulation of immunoglobulin production [GO:0002637],
DNA repair [GO:0006281],
cellular response to DNA damage stimulus [GO:0006974],
determination of adult lifespan [GO:0008340],
positive regulation of cGMP-mediated signaling [GO:0010753],
viral process [GO:0016032],
positive regulation of type I interferon production [GO:0032481],
paracrine signaling [GO:0038001],
positive regulation of cAMP-mediated signaling [GO:0043950],
innate immune response [GO:0045087],
regulation of T cell activation [GO:0050863],
defense response to virus [GO:0051607],
cellular response to exogenous dsRNA [GO:0071360],
negative regulation of double-strand break repair via homologous recombination [GO:2000042],
positive regulation of cellular senescence [GO:2000774],
immune system process [GO:0002376],
regulation of type I interferon production [GO:0032479],
regulation of immune response [GO:0050776],

Molecular Function:
DNA binding [GO:0003677],
chromatin binding [GO:0003682],
double-stranded DNA binding [GO:0003690],
protein binding [GO:0005515],
ATP binding [GO:0005524],
GTP binding [GO:0005525],
phosphatidylinositol-4,5-bisphosphate binding [GO:0005546],
metal ion binding [GO:0046872],
cyclic-GMP-AMP synthase activity [GO:0061501],
nucleotide binding [GO:0000166],
lipid binding [GO:0008289],
transferase activity [GO:0016740],
nucleotidyltransferase activity [GO:0016779],

Cellular Component:
nucleus [GO:0005634],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
site of double-strand break [GO:0035861],
cytoplasm [GO:0005737],
membrane [GO:0016020],