CFL1

cofilin 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
30901604 UW228 Human NO
33184359 Liver,skin Mouse No

GO terms:

Biological Process:
mitotic cytokinesis [GO:0000281],
neural crest cell migration [GO:0001755],
neural fold formation [GO:0001842],
protein phosphorylation [GO:0006468],
cytoskeleton organization [GO:0007010],
Rho protein signal transduction [GO:0007266],
response to virus [GO:0009615],
regulation of cell morphogenesis [GO:0022604],
establishment of cell polarity [GO:0030010],
actin cytoskeleton organization [GO:0030036],
actin filament depolymerization [GO:0030042],
actin filament fragmentation [GO:0030043],
positive regulation of actin filament depolymerization [GO:0030836],
interleukin-12-mediated signaling pathway [GO:0035722],
negative regulation of apoptotic process [GO:0043066],
response to amino acid [GO:0043200],
positive regulation by host of viral process [GO:0044794],
cell motility [GO:0048870],
actin filament severing [GO:0051014],
regulation of dendritic spine morphogenesis [GO:0061001],
protein import into nucleus [GO:0006606],
movement of cell or subcellular component [GO:0006928],
actin filament organization [GO:0007015],
negative regulation of cell adhesion [GO:0007162],
positive regulation of lamellipodium assembly [GO:0010592],
negative regulation of lamellipodium assembly [GO:0010593],
cell projection organization [GO:0030030],
positive regulation of cell growth [GO:0030307],
negative regulation of actin filament depolymerization [GO:0030835],
positive regulation of synaptic plasticity [GO:0031915],
negative regulation of actin filament bundle assembly [GO:0032232],
negative regulation of cell size [GO:0045792],
positive regulation of proteolysis [GO:0045862],
negative regulation of unidimensional cell growth [GO:0051511],
positive regulation of focal adhesion assembly [GO:0051894],
positive regulation of dendritic spine development [GO:0060999],
cellular response to hydrogen peroxide [GO:0070301],
cellular response to interleukin-1 [GO:0071347],
cellular response to interleukin-6 [GO:0071354],
cellular response to tumor necrosis factor [GO:0071356],
cellular response to epidermal growth factor stimulus [GO:0071364],
modification of postsynaptic actin cytoskeleton [GO:0098885],
negative regulation of dendritic spine maintenance [GO:1902951],
positive regulation of NMDA glutamate receptor activity [GO:1904783],
cellular response to insulin-like growth factor stimulus [GO:1990314],
negative regulation of cell motility [GO:2000146],
positive regulation of cell motility [GO:2000147],
positive regulation of establishment of cell polarity regulating cell shape [GO:2000784],
positive regulation of barbed-end actin filament capping [GO:2000814],

Molecular Function:
receptor binding [GO:0005102],
protein binding [GO:0005515],
actin filament binding [GO:0051015],
actin binding [GO:0003779],
protein phosphatase binding [GO:0019903],
phosphatidylinositol bisphosphate binding [GO:1902936],

Cellular Component:
extracellular space [GO:0005615],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
cell-cell junction [GO:0005911],
focal adhesion [GO:0005925],
actin cytoskeleton [GO:0015629],
membrane [GO:0016020],
nuclear matrix [GO:0016363],
lamellipodium [GO:0030027],
actin cortical patch [GO:0030479],
cortical actin cytoskeleton [GO:0030864],
lamellipodium membrane [GO:0031258],
vesicle [GO:0031982],
ruffle membrane [GO:0032587],
extracellular exosome [GO:0070062],
extracellular region [GO:0005576],
intracellular [GO:0005622],
cytoskeleton [GO:0005856],
plasma membrane [GO:0005886],
filopodium [GO:0030175],
growth cone [GO:0030426],
cell leading edge [GO:0031252],
mitochondrial membrane [GO:0031966],
cell projection [GO:0042995],
neuron projection [GO:0043005],
neuronal cell body [GO:0043025],
dendritic spine [GO:0043197],
synaptic membrane [GO:0097060],
glutamatergic synapse [GO:0098978],