CEL

carboxyl ester lipase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Li Fraumeni Human YES
30626320 HBEC Human NO
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
lipid metabolic process [GO:0006629],
cholesterol catabolic process [GO:0006707],
neuron cell-cell adhesion [GO:0007158],
chemical synaptic transmission [GO:0007268],
fatty acid catabolic process [GO:0009062],
protein esterification [GO:0018350],
pancreatic juice secretion [GO:0030157],
intestinal cholesterol absorption [GO:0030299],
lipid digestion [GO:0044241],
intestinal lipid catabolic process [GO:0044258],
synaptic vesicle endocytosis [GO:0048488],
modulation of synaptic transmission [GO:0050804],
postsynaptic membrane assembly [GO:0097104],
presynaptic membrane assembly [GO:0097105],
lipid catabolic process [GO:0016042],
ceramide catabolic process [GO:0046514],

Molecular Function:
catalytic activity [GO:0003824],
sterol esterase activity [GO:0004771],
triglyceride lipase activity [GO:0004806],
protein binding [GO:0005515],
acetylesterase activity [GO:0008126],
heparin binding [GO:0008201],
hydrolase activity [GO:0016787],
signaling receptor activity [GO:0038023],
neurexin family protein binding [GO:0042043],
lysophospholipase activity [GO:0004622],
hydrolase activity, acting on ester bonds [GO:0016788],
glycosphingolipid binding [GO:0043208],
macromolecular complex binding [GO:0044877],
retinyl-palmitate esterase activity [GO:0050253],
carboxylic ester hydrolase activity [GO:0052689],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
cytoplasm [GO:0005737],
integral component of plasma membrane [GO:0005887],
cell surface [GO:0009986],
synapse [GO:0045202],
extracellular exosome [GO:0070062],
presynapse [GO:0098793],
rough endoplasmic reticulum [GO:0005791],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
macromolecular complex [GO:0032991],
zymogen granule [GO:0042588],
intracellular membrane-bounded organelle [GO:0043231],
membrane raft [GO:0045121],