CEBPB

CCAAT enhancer binding protein beta

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
16107878 MEF Mouse NO
20818427 WI-38 Human NO
21353395 Primary chrondrocytes derived from articular cartilage Articular cartilage Mouse NO
21804532 NIH 3T3, IMR-90 Human, mouse NO
21980398 WI-38 Human NO
25772238 LNCaP Human NO
30988157 IMR-90 Human YES
31183403 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
25472717 Primary fibroblasts derived from heart Mouse NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
ovarian follicle development [GO:0001541],
embryonic placenta development [GO:0001892],
regulation of transcription, DNA-templated [GO:0006355],
transcription from RNA polymerase II promoter [GO:0006366],
acute-phase response [GO:0006953],
inflammatory response [GO:0006954],
immune response [GO:0006955],
memory [GO:0007613],
neuron differentiation [GO:0030182],
positive regulation of interleukin-4 production [GO:0032753],
mammary gland epithelial cell proliferation [GO:0033598],
response to endoplasmic reticulum stress [GO:0034976],
negative regulation of T cell proliferation [GO:0042130],
defense response to bacterium [GO:0042742],
negative regulation of neuron apoptotic process [GO:0043524],
regulation of interleukin-6 biosynthetic process [GO:0045408],
positive regulation of fat cell differentiation [GO:0045600],
positive regulation of osteoblast differentiation [GO:0045669],
regulation of osteoclast differentiation [GO:0045670],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of inflammatory response [GO:0050729],
brown fat cell differentiation [GO:0050873],
mammary gland epithelial cell differentiation [GO:0060644],
regulation of transcription involved in cell fate commitment [GO:0060850],
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059],
positive regulation of biomineral tissue development [GO:0070169],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to amino acid stimulus [GO:0071230],
cellular response to interleukin-1 [GO:0071347],
cellular response to organic cyclic compound [GO:0071407],
hepatocyte proliferation [GO:0072574],
liver regeneration [GO:0097421],
regulation of odontoblast differentiation [GO:1901329],
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440],
positive regulation of sodium-dependent phosphate transport [GO:2000120],
regulation of dendritic cell differentiation [GO:2001198],
granuloma formation [GO:0002432],
positive regulation of gene expression [GO:0010628],
cell differentiation [GO:0030154],
response to lipopolysaccharide [GO:0032496],
T-helper 1 cell activation [GO:0035711],
fat cell differentiation [GO:0045444],
negative regulation of transcription, DNA-templated [GO:0045892],

Molecular Function:
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001227],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
DNA binding [GO:0003677],
chromatin binding [GO:0003682],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
protein binding [GO:0005515],
kinase binding [GO:0019900],
histone acetyltransferase binding [GO:0035035],
glucocorticoid receptor binding [GO:0035259],
protein homodimerization activity [GO:0042803],
histone deacetylase binding [GO:0042826],
ubiquitin-like protein ligase binding [GO:0044389],
protein heterodimerization activity [GO:0046982],
transcription regulatory region sequence-specific DNA binding [GO:0000976],
transcription factor binding [GO:0008134],
identical protein binding [GO:0042802],
sequence-specific DNA binding [GO:0043565],

Cellular Component:
condensed chromosome, centromeric region [GO:0000779],
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
nuclear matrix [GO:0016363],
CHOP-C/EBP complex [GO:0036488],
RNA polymerase II transcription factor complex [GO:0090575],