CEBPA

CCAAT enhancer binding protein alpha

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
19805226 Primary CD4+ T cells derived from spleen Mouse NO
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Saos-2, Li-Fraumeni Human YES

GO terms:

Biological Process:
urea cycle [GO:0000050],
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
liver development [GO:0001889],
embryonic placenta development [GO:0001892],
generation of precursor metabolites and energy [GO:0006091],
transcription, DNA-templated [GO:0006351],
transcription from RNA polymerase II promoter [GO:0006366],
mitochondrion organization [GO:0007005],
Notch signaling pathway [GO:0007219],
cholesterol metabolic process [GO:0008203],
negative regulation of cell proliferation [GO:0008285],
viral process [GO:0016032],
cytokine-mediated signaling pathway [GO:0019221],
myeloid cell differentiation [GO:0030099],
macrophage differentiation [GO:0030225],
lung development [GO:0030324],
granulocyte differentiation [GO:0030851],
positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436],
glucose homeostasis [GO:0042593],
positive regulation of macrophage activation [GO:0043032],
fat cell differentiation [GO:0045444],
positive regulation of fat cell differentiation [GO:0045600],
positive regulation of osteoblast differentiation [GO:0045669],
negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of transcription from RNA polymerase III promoter [GO:0045945],
cell maturation [GO:0048469],
inner ear development [GO:0048839],
positive regulation of inflammatory response [GO:0050729],
white fat cell differentiation [GO:0050872],
brown fat cell differentiation [GO:0050873],
lipid homeostasis [GO:0055088],
interleukin-6-mediated signaling pathway [GO:0070102],
cellular response to lithium ion [GO:0071285],
cellular response to tumor necrosis factor [GO:0071356],
cellular response to organic cyclic compound [GO:0071407],
regulation of transcription, DNA-templated [GO:0006355],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
transcription from RNA polymerase I promoter [GO:0006360],
multicellular organism development [GO:0007275],
positive regulation of gene expression [GO:0010628],
regulation of cell proliferation [GO:0042127],
negative regulation of cell cycle [GO:0045786],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of DNA-templated transcription, initiation [GO:2000144],

Molecular Function:
transcription regulatory region sequence-specific DNA binding [GO:0000976],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
DNA binding [GO:0003677],
chromatin binding [GO:0003682],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
transcription coactivator activity [GO:0003713],
protein binding [GO:0005515],
transcription factor binding [GO:0008134],
kinase binding [GO:0019900],
protein homodimerization activity [GO:0042803],
RNA polymerase I regulatory region sequence-specific DNA binding [GO:0001163],
protein domain specific binding [GO:0019904],
identical protein binding [GO:0042802],
histone deacetylase binding [GO:0042826],
sequence-specific DNA binding [GO:0043565],
macromolecular complex binding [GO:0044877],
protein heterodimerization activity [GO:0046982],
HMG box domain binding [GO:0071837],

Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
transcription factor complex [GO:0005667],
nucleolus [GO:0005730],
intracellular membrane-bounded organelle [GO:0043231],
RNA polymerase II transcription factor complex [GO:0090575],
nuclear matrix [GO:0016363],
macromolecular complex [GO:0032991],
Rb-E2F complex [GO:0035189],
CHOP-C/EBP complex [GO:0036488],