CEACAM1

CEA cell adhesion molecule 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES
29548335 Saos-2, Li-Fraumeni Human YES

GO terms:

Biological Process:
angiogenesis [GO:0001525],
regulation of cell growth [GO:0001558],
blood vessel development [GO:0001568],
negative regulation of T cell mediated cytotoxicity [GO:0001915],
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002859],
negative regulation of protein kinase activity [GO:0006469],
cell adhesion [GO:0007155],
homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156],
integrin-mediated signaling pathway [GO:0007229],
regulation of endothelial cell migration [GO:0010594],
regulation of phosphatidylinositol 3-kinase signaling [GO:0014066],
bile acid and bile salt transport [GO:0015721],
cell migration [GO:0016477],
regulation of cell migration [GO:0030334],
negative regulation of granulocyte differentiation [GO:0030853],
negative regulation of interleukin-1 production [GO:0032692],
cellular response to insulin stimulus [GO:0032869],
common myeloid progenitor cell proliferation [GO:0035726],
insulin receptor internalization [GO:0038016],
granulocyte colony-stimulating factor signaling pathway [GO:0038158],
regulation of epidermal growth factor receptor signaling pathway [GO:0042058],
negative regulation of vascular permeability [GO:0043116],
neutrophil degranulation [GO:0043312],
negative regulation of cytotoxic T cell degranulation [GO:0043318],
wound healing, spreading of cells [GO:0044319],
regulation of endothelial cell differentiation [GO:0045601],
negative regulation of fatty acid biosynthetic process [GO:0045717],
negative regulation of T cell receptor signaling pathway [GO:0050860],
leukocyte migration [GO:0050900],
negative regulation of lipid biosynthetic process [GO:0051055],
regulation of blood vessel remodeling [GO:0060312],
regulation of ERK1 and ERK2 cascade [GO:0070372],
negative regulation of platelet aggregation [GO:0090331],
cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742],
insulin catabolic process [GO:1901143],
regulation of homophilic cell adhesion [GO:1903385],
regulation of sprouting angiogenesis [GO:1903670],
negative regulation of hepatocyte proliferation [GO:2000346],
positive regulation of vasculogenesis [GO:2001214],
negative regulation of cytokine production [GO:0001818],
viral process [GO:0016032],
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338],
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339],
negative regulation of interleukin-2 production [GO:0032703],
positive regulation of T cell proliferation [GO:0042102],
negative regulation of T cell proliferation [GO:0042130],
positive regulation of MAP kinase activity [GO:0043406],
negative regulation by host of viral process [GO:0044793],
positive regulation by host of viral process [GO:0044794],
negative regulation by host of viral genome replication [GO:0044828],
cell-cell junction organization [GO:0045216],
negative regulation of osteoclast differentiation [GO:0045671],
negative regulation of bone resorption [GO:0045779],
negative regulation of JNK cascade [GO:0046329],
positive regulation of JNK cascade [GO:0046330],
viral entry into host cell [GO:0046718],
Peyer's patch development [GO:0048541],
positive regulation of immunoglobulin secretion [GO:0051024],
positive regulation of activation-induced cell death of T cells [GO:0070237],
positive regulation of calcineurin-NFAT signaling cascade [GO:0070886],
positive regulation of CD4-positive, alpha-beta T cell activation [GO:2000516],
positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563],
positive regulation of CD8-positive, alpha-beta T cell activation [GO:2001187],

Molecular Function:
molecular_function [GO:0003674],
actin binding [GO:0003779],
protein binding [GO:0005515],
calmodulin binding [GO:0005516],
bile acid transmembrane transporter activity [GO:0015125],
kinase binding [GO:0019900],
protein phosphatase binding [GO:0019903],
filamin binding [GO:0031005],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
protein dimerization activity [GO:0046983],
protein tyrosine kinase binding [GO:1990782],
virus receptor activity [GO:0001618],
granulocyte colony-stimulating factor receptor binding [GO:0005130],
protein kinase binding [GO:0019901],
Toll-like receptor binding [GO:0035325],
virion binding [GO:0046790],

Cellular Component:
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
cell-cell junction [GO:0005911],
adherens junction [GO:0005912],
basal plasma membrane [GO:0009925],
cell surface [GO:0009986],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
apical plasma membrane [GO:0016324],
lateral plasma membrane [GO:0016328],
cell junction [GO:0030054],
transport vesicle membrane [GO:0030658],
microvillus membrane [GO:0031528],
specific granule membrane [GO:0035579],
T cell receptor complex [GO:0042101],
extracellular exosome [GO:0070062],
tertiary granule membrane [GO:0070821],
extracellular space [GO:0005615],
external side of plasma membrane [GO:0009897],
cytoplasmic vesicle [GO:0031410],
brush border membrane [GO:0031526],
cell projection [GO:0042995],
ciliary membrane [GO:0060170],