adenylate cyclase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2, Li-Fraumeni Human YES
31155234 heart heart Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
30987592 MCF7 Breast Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
renal water homeostasis [GO:0003091],
cAMP biosynthetic process [GO:0006171],
G-protein coupled receptor signaling pathway [GO:0007186],
adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189],
activation of adenylate cyclase activity [GO:0007190],
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [GO:0007193],
axonogenesis [GO:0007409],
brain development [GO:0007420],
long-term memory [GO:0007616],
circadian rhythm [GO:0007623],
response to lithium ion [GO:0010226],
cAMP-mediated signaling [GO:0019933],
positive regulation of CREB transcription factor activity [GO:0032793],
activation of protein kinase A activity [GO:0034199],
regulation of circadian rhythm [GO:0042752],
cellular response to calcium ion [GO:0071277],
cellular response to glucagon stimulus [GO:0071377],
positive regulation of long-term synaptic potentiation [GO:1900273],
cellular response to forskolin [GO:1904322],
regulation of synaptic vesicle exocytosis [GO:2000300],
cyclic nucleotide biosynthetic process [GO:0009190],
intracellular signal transduction [GO:0035556],
rhythmic process [GO:0048511],
modulation of synaptic transmission [GO:0050804],

Molecular Function:
adenylate cyclase activity [GO:0004016],
calmodulin binding [GO:0005516],
ATP binding [GO:0005524],
calcium- and calmodulin-responsive adenylate cyclase activity [GO:0008294],
metal ion binding [GO:0046872],
nucleotide binding [GO:0000166],
lyase activity [GO:0016829],
phosphorus-oxygen lyase activity [GO:0016849],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
membrane raft [GO:0045121],
extracellular exosome [GO:0070062],
glutamatergic synapse [GO:0098978],
integral component of postsynaptic density membrane [GO:0099061],
postsynaptic density [GO:0014069],
membrane [GO:0016020],
integral component of membrane [GO:0016021],