ADAR

adenosine deaminase RNA specific

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

GO terms:

Biological Process:
osteoblast differentiation [GO:0001649],
hematopoietic progenitor cell differentiation [GO:0002244],
somatic diversification of immune receptors via somatic mutation [GO:0002566],
adenosine to inosine editing [GO:0006382],
RNA processing [GO:0006396],
mRNA processing [GO:0006397],
response to virus [GO:0009615],
base conversion or substitution editing [GO:0016553],
erythrocyte differentiation [GO:0030218],
pre-miRNA processing [GO:0031054],
miRNA loading onto RISC involved in gene silencing by miRNA [GO:0035280],
response to interferon-alpha [GO:0035455],
negative regulation of apoptotic process [GO:0043066],
negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387],
positive regulation of viral genome replication [GO:0045070],
innate immune response [GO:0045087],
defense response to virus [GO:0051607],
definitive hemopoiesis [GO:0060216],
type I interferon signaling pathway [GO:0060337],
negative regulation of type I interferon-mediated signaling pathway [GO:0060339],
hematopoietic stem cell homeostasis [GO:0061484],
cellular response to virus [GO:0098586],
negative regulation of RNA interference [GO:1900369],
in utero embryonic development [GO:0001701],
immune system process [GO:0002376],
protein import into nucleus [GO:0006606],
protein export from nucleus [GO:0006611],
gene silencing by RNA [GO:0031047],
production of miRNAs involved in gene silencing by miRNA [GO:0035196],
negative regulation of viral genome replication [GO:0045071],

Molecular Function:
DNA binding [GO:0003677],
RNA binding [GO:0003723],
double-stranded RNA binding [GO:0003725],
double-stranded RNA adenosine deaminase activity [GO:0003726],
protein binding [GO:0005515],
tRNA-specific adenosine deaminase activity [GO:0008251],
metal ion binding [GO:0046872],
left-handed Z-DNA binding [GO:0003692],
adenosine deaminase activity [GO:0004000],
hydrolase activity [GO:0016787],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],
cytoplasm [GO:0005737],
membrane [GO:0016020],
supraspliceosomal complex [GO:0044530],
nuclear speck [GO:0016607],