CDKN2A

cyclin dependent kinase inhibitor 2A

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31981461 Liver, artery, adipose tissue, intestine, kidney, pancreas, spleen, brain, lung, skin, heart, muscle Mouse NO
Primary keratinocytes derived from skin Skin Human NO
10763818 U-2 OS Human NO
10825132 Epithelial cells derived from prostate gland Human NO
11481442 Primary pre- B cells derived from Bone marrow Mouse NO
11983028 C6 Brain Rat NO
11995925 TIG-7 Human NO
12077343 R2F, HM3, OKF4, HuCL-22, ConjEp-1, K17, POE9n Skin Human NO
12150825 MEF Mouse NO
12392077 TIG-7 Human NO
12482990 WI-38, 82-6, BJ Human NO
12759390 Hmel-p16-1,WMM1175, SK-MEL-23, A375P, COLO 858, MCF7 Human NO
12912919 WI‐38, BJ Human NO
14604992 MRT Human NO
14720514 Primary follicular epithelial cells derived from thymus Human NO
15026580 Primary chondrocytes derived from articular cartilage Human NO
15138269 2BS Human NO
15149756 Normal Human urothelium Human NO
15308640 MRC-5 Human NO
15340528 A549 Human NO
15668906 IMR-90, U2OS, HeLA Human NO
15781639 Psi 2, B16, WM266-4, Melan-c Skin, Breast Human, mouse NO
15888044 Kidney Human NO
15964994 Brain cerebellum Mouse NO
16243918 HUVEC Human NO
16254068 Primary mesothelial cells derived peritoneal tissue Human NO
16723698 SCC-13, OKF4, POE-9n, SCC-71 Skin Human NO
16767161 HFKs Human NO
16880792 Primary melanocytes Skin Human NO
16912158 MEF Mouse NO
17028578 TIG-3, Hs68 Human NO
17225865 2BS Lung Human NO
17233832 HBEC, HDK, HDPC, HFK, HMEC, HPrEC, HSAEC Human NO
17344414 TIG-3, MEF Human, mouse NO
17447021 WI-38 Human NO
17452980 MECs Human NO
17475325 Neoplastic lymphoid cells Human NO
17569790 Primary mesenchymal stem cells derived from bone marrow Human NO
17576930 Primary melanocytes derived from skin Skin Mouse NO
17638879 Fetal cells derived from sleletal muscle Human NO
17989730 Primary dermal papilla cells derived from hair follicle Human NO
18504326 Kidney, Heart Human, rat NO
18516091 Adipose, Skeletal muscle Mouse NO
18544633 WI-38 Human NO
18558095 NCI-H46, HEK 293T Human NO
18591425 MEF Skin, Limb Mouse NO
18596985 MEF Mouse NO
18662989 Primary cells derived from prostate gland Prostate gland Human NO
18676825 Primary fibroblasts and keratinocytes derived from foreskin Human NO
Primary cells derived from nucleus pulposus Intervertebral disc
18843795 WMM1175 Human NO
19124561 EPCs Human NO
19308294 MSCs Mouse NO
19380490 MEF Mouse NO
19398954 Hematopoietic stem cells derived from bone marrow Mouse NO
19462008 MEF Mouse NO
19723773 MEF Mouse NO
20157537 WMM1175, HEM Human NO
20708155 Colon, Lung Mouse NO
20969773 MCF7, Bovine Mammary Epithelial Cells (BMEC) Mammary gland Human, bovine NO
21187925 EPCs Human NO
21233453 Great saphenous vein Mouse NO
21368868 embryonic NSC Rat NO
21933340 BJ, WS1, MDA-MB-231, T47D Human NO
22733129 MEF, IMR-90 Human, mouse NO
22754337 MEF Mouse NO
22829758 Lung Human NO
22935696 MDA-MB-232 Human NO
23455154 IMR-90 Human NO
23730211 MDA-MB-232 Human NO
23949224 MEF Mouse NO
23974099 HT-18 Human NO
24167583 BEAS-2B Lung Human NO
24217920 HMECs Human NO
24307508 Primary progenitor cells derived from blood Human, mouse NO
24522534 Geriatric stem cells derived from muscle Mouse NO
24572376 Primary chondrocytes derived from cartilage Human NO
24588771 SGC-791 Human NO
24676500 Stem cells derived from dental pulp Human NO
24807532 Primary cells derived from liver Human NO
24950189 Primary endothelial cells derived from human Human NO
24960204 MAFs Kidney, Liver, Gut, Lung, Skin Mouse NO
25029561 HPNE Human NO
25181340 HEKs Human NO
25304494 Mesenchymal stem cells derived from dental pulp Human NO
25567807 RTECs Human NO
25674264 Cervix Human NO
26500063 IMR-90 Skin Human NO
26528722 Sinusoidal endothelial cells derived from liver Mouse NO
26718972 MEF Mouse NO
26950362 Primary beta cells derived from pancreas Human, mouse NO
27457128 U2OS, Saos-2, HeLa, MCF7, MDA-MB-231, H1299, TIG, MRC5, WI41 Human NO
27591832 Primary CD3+ T-cells derived from peritheral blood Human NO
27739458 HCEC Human NO
27743340 HDFs Human NO
27872202 WMM1175, SK-MEL-13 Skin Human NO
28120917 HEK 293T Human NO
28184004 NHC Human NO
28278054 MECs Mammary glands Mouse NO
28410532 Stem cells derived from dental pulp Human NO
28425986 HEK 293T Retina Human, mouse NO
28770470 Primary cells from dental follicle Human NO
28790310 Primary fibroblasts derived from kidney Kidney Mouse NO
28892048 HPDE-6 Pancreas Human, mouse NO
28938531 Left atrial appendages Human NO
28942143 HPNE, BxPC-3, HEK 293T Human NO
29133799 Primary myoepithelial cells from breast Human NO
29245970 786-O, ACHN Human NO
29267490 Primary dermal papilla cells derived from hair follicle Human NO
29280266 Pancreas Mouse NO
29356545 HEK 293T, U87 Human NO
29744983 Primary chondrocytes derived from articular cartilage Hindlimb Human, mouse NO
29748384 MEF, A549,H1299,H1341,GM847 Spleen, Skin, Testes Human, mouse NO
30401703 Primary cells derived from bone marrow Human NO
30443193 Stem cells derived from embryo Human NO
30590424 Primary stromovascular fractions derived from adipose tissue Mouse NO
30968547 Primary epithelial cells derived from thymus Mouse NO
30977425 Primary mononuclear cells derived from blood Rat NO
30998584 Brain Mouse NO
31001908 Primary fibroblasts derived from skin , WM793 Human, mouse NO
31004310 Primary mononuclear cells derived from blood Human NO
31035086 HK-2 Human NO
31047988 Heart Mouse NO
31059057 OVCA429,OVCA434 Human NO
31080015 Primary stem cells derived from endometrium Uterus Human, mouse NO
31085244 MEF Mouse NO
31085283 NB1, HEKN,U-2 OS, 201B7 Human NO
31091306 Primary Schwann cells derived spinal cord, primary mesenchymal cells derived from bone marrow Spine, muscle Human, Mouse NO
31144244 Primary fibroblasts derived from skin Human NO
31148378 MRC-5 Human
31155496 Pancreas Human NO
31158467 Primary mesangial cells derived from kidney Kidney Human, rat NO
31158660 Primary endothelial cells derived from artery Pig NO
31160572 Primary melanocytes derived from skin Skin, lung Human,Mouse NO
31162503 Primary endothelial cells derived from umbilical vein Human NO
31165161 Intensine Mouse NO
31182708 Primary fibroblasts derived from skin, HaCaT Skin, intensine, tongue Human, mouse, rat NO
31184599 Prostate, breast, skin Human NO
31189923 Primary satellite cells derived from skeletal muscle Muscle Mouse NO
31209047 IMR-90, MEF Human,Mouse NO
31209329 Primary stromal cells derived from adipose tissue, primary fibroblasts derived from skin Human NO
31218816 Primary mesenchymal stromal cells derived from fetal bone marrow Human NO
31250942 BT-549 Human NO
31424120 Placenta Mouse NO
31428639 Primary stem cells derived from bone marrow Human NO
31432132 Primary stem cells derived from periodontal ligament Human NO
31433975 IMR-90 Human NO
31439890 NCI-H1299 Human NO
31461302 Lung Human, mouse NO
31469894 Cornea Mouse NO
31471533 Primary cells derived from nucleus pulposus Rat NO
31481873 HT22 Mouse NO
31503005 MEF Mouse NO
31503007 SMMC-7721, Hep G2 Human NO
31512783 Primary cells derived from prostate Human NO
31513781 HBMEC Human NO
31517418 Hep G2 Human NO
31520547 WI-38 Human NO
31521202 Primary stem cells derived from mesenchyma Human NO
31533987 TIG-1 Human NO
31552414 HMVEC Human NO
31595820 MEF Mouse NO
31636448 Primary neuron derived from brain, HT-22 Mouse NO
31670873 Pectoral fin Zebrafish NO
31752013 HUVEC Human NO
31752674 Primary mesenchymal cells derived from bone Rat NO
31762159 Primary neurons derived from brain Rat NO
31819167 TIG-3 Human NO
31860636 2BS, 293T  Human YES
31931659 WI-38 Human NO
31945125 Primary astrocytes derived from brain Human YES
31971661 Primary mesenchymal stem cells derived from adipose tissue Mouse YES
31976028 Primary nucleus pulposus derived from intervertebral disc Human NO
32029712 Primary synovial fibroblast Human YES
9486850 MDAH41, MDAH87 Human NO
30474138 Primary mesenchymal stem cells derived from dental pulp, primary mesenchymal stem cells derived from gingiva, primary mesenchymal stem cells derived from periodontal ligament Human NO
31091306 Primary Schwann cells derived spinal cord, primary mesenchymal cells derived from bone marrow Spine, muscle Human, Mouse NO
31227697 Primary mesenchymal progenitor cells derived from adipose tissue, primary stromal vascular cells derived from adipose tissue Human NO
32991320 Zebrafish NO
32687062 HTC75 Human NO
32611834 Primary cells derived from cartilage Cartilage Human NO
32304210 Primary cells derived from adipose tissue Human NO
32634429 Primary mesenchymal cells derived from adipose tissue Human NO
32954665 KYSE-450  Human NO
32523550 HCASMC Human No
33495462 SW 1353 Human No
32599680 SW480 Human No
32963699 Primary cells derived from mesenchyma, Primary endothelial cells derived from aorta Human No
32963699 Primary cells derived from mesenchyma, Primary endothelial cells derived from aorta Human No
32622876 Primary chondrocytes derived from cartilage Human No
32662244 hTERT RPE-1 Human No
32976914 Primary fibroblasts derived from skin Human No
32991815 Primary alveolar type II cells derived from lung Human NO
32427330 Primary mesenchymal stem cells Human NO
32989246 IMR90 Human NO
31943227 Primary fibroblast derived from oral cavity Human NO
31792920 HUVEC Human NO
32360904 LNCaP Human NO
33126704 Skin Human NO
32460521 Primary fibroblasts derived from lung Human NO
33279583 LP-9 Human NO
32466233 TIG-3, RPE-1 Human NO
32570219 Primary fibroblasts derived from skin Human NO
32993785 HUVEC, 4T1 Human NO
33428925 MEF, NHBE Human No
32346137 HUVEC Artery Human NO
32671444 MDA-MB-231 Breast Human NO
33184359 HDF Liver, skin Human No
32991321 C6 ATCC, U-87MG Human NO
32727916 Artery Human No
32570219 Primary fibroblasts derived from skin mouse NO
32993785 HUVEC, 4T1 mouse NO
33428925 MEF, NHBE mouse No
32346137 HUVEC Artery mouse NO
32671444 MDA-MB-231 Breast mouse NO
33184359 HDF Liver, skin mouse No
32341413 Liver, kidney Mouse No
33038325 Primary neurons derived from brain brain Mouse No
33115945 Primary cells derived from heart Mouse No
33299530 kidney Mouse No
33470505 brain Mouse No
32802505 Primary Aortic Smooth Muscle Cells Mouse No
32840323 15P-1 Mouse No
32527988 Intervertebral disc Mouse NO
32839595 MEF Mouse NO
32070140 Lung Mouse NO
33154378 Primary mesenchymal stem cells derived from bone Mouse NO
32439975 Retina Mouse NO
32991321 C6 ATCC, U-87MG rat NO
32727916 Artery rat No
32634782 Brain, pancreas, intestine Rat NO
32508743 Brain Rat NO
33046751 Muscle Rat NO
32068317 F111 Rat NO
32753470 Rat2 Rat No
32727916 Vessel Rat No
32952639 Primary chondrocyte derived from cartilage Rat NO
33010296 Kidney Rat NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
25270420 Primary cells derived from liver Mouse NO
29321003 Primary bronchial epithelial cells derived from lung Human YES
31642042 HDF Human NO
31773901  2BS, WI-38  Human NO
32127793 Brown adipose Mouse NO

GO terms:

Biological Process:
G1/S transition of mitotic cell cycle [GO:0000082],
negative regulation of cell-matrix adhesion [GO:0001953],
cell cycle arrest [GO:0007050],
Ras protein signal transduction [GO:0007265],
negative regulation of cell proliferation [GO:0008285],
negative regulation of cell growth [GO:0030308],
negative regulation of NF-kappaB transcription factor activity [GO:0032088],
positive regulation of smooth muscle cell apoptotic process [GO:0034393],
senescence-associated heterochromatin focus assembly [GO:0035986],
negative regulation of phosphorylation [GO:0042326],
negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736],
negative regulation of transcription, DNA-templated [GO:0045892],
cellular senescence [GO:0090398],
replicative senescence [GO:0090399],
positive regulation of macrophage apoptotic process [GO:2000111],
negative regulation of G1/S transition of mitotic cell cycle [GO:2000134],
positive regulation of cellular senescence [GO:2000774],
regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079],
protein polyubiquitination [GO:0000209],
mitophagy [GO:0000422],
rRNA processing [GO:0006364],
negative regulation of protein kinase activity [GO:0006469],
apoptotic process [GO:0006915],
activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919],
cell cycle [GO:0007049],
aging [GO:0007568],
cell aging [GO:0007569],
epidermis development [GO:0008544],
apoptotic mitochondrial changes [GO:0008637],
rRNA transcription [GO:0009303],
response to organonitrogen compound [GO:0010243],
regulation of G2/M transition of mitotic cell cycle [GO:0010389],
regulation of gene expression [GO:0010468],
positive regulation of gene expression [GO:0010628],
response to organic cyclic compound [GO:0014070],
negative regulation of B cell proliferation [GO:0030889],
regulation of protein stability [GO:0031647],
protein destabilization [GO:0031648],
negative regulation of protein binding [GO:0032091],
negative regulation of immature T cell proliferation in thymus [GO:0033088],
positive regulation of protein sumoylation [GO:0033235],
negative regulation of mammary gland epithelial cell proliferation [GO:0033600],
somatic stem cell population maintenance [GO:0035019],
response to drug [GO:0042493],
glucose homeostasis [GO:0042593],
positive regulation of apoptotic process [GO:0043065],
positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517],
negative regulation of cell cycle [GO:0045786],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
regulation of nucleocytoplasmic transport [GO:0046822],
regulation of protein export from nucleus [GO:0046825],
somatic stem cell division [GO:0048103],
protein stabilization [GO:0050821],
regulation of sequence-specific DNA binding transcription factor activity [GO:0051090],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
negative regulation of ubiquitin-protein transferase activity [GO:0051444],
mitochondrial depolarization [GO:0051882],
positive regulation of apoptotic process involved in mammary gland involution [GO:0060058],
cellular response to hydrogen peroxide [GO:0070301],
protein K63-linked ubiquitination [GO:0070534],
positive regulation of cell cycle arrest [GO:0071158],
positive regulation of protein localization to nucleus [GO:1900182],
positive regulation of signal transduction by p53 class mediator [GO:1901798],
regulation of apoptotic DNA fragmentation [GO:1902510],
negative regulation of proteolysis involved in cellular protein catabolic process [GO:1903051],
regulation of protein targeting to mitochondrion [GO:1903214],
negative regulation of ubiquitin protein ligase activity [GO:1904667],
amyloid fibril formation [GO:1990000],
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000059],
negative regulation of hepatocyte proliferation [GO:2000346],
negative regulation of protein neddylation [GO:2000435],

Molecular Function:
RNA binding [GO:0003723],
cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861],
protein binding [GO:0005515],
protein kinase binding [GO:0019901],
NF-kappaB binding [GO:0051059],
p53 binding [GO:0002039],
DNA binding [GO:0003677],
transcription factor binding [GO:0008134],
SUMO transferase activity [GO:0019789],
protein N-terminus binding [GO:0047485],
ubiquitin-protein transferase inhibitor activity [GO:0055105],
MDM2/MDM4 family protein binding [GO:0097371],
disordered domain specific binding [GO:0097718],
ubiquitin ligase inhibitor activity [GO:1990948],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
senescence-associated heterochromatin focus [GO:0035985],
granular component [GO:0001652],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],
mitochondrion [GO:0005739],
nuclear body [GO:0016604],
macromolecular complex [GO:0032991],