ADAMTS8

ADAM metallopeptidase with thrombospondin type 1 motif 8

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

GO terms:

Biological Process:
proteolysis [GO:0006508],
negative regulation of cell proliferation [GO:0008285],
extracellular matrix organization [GO:0030198],
phosphate ion transmembrane transport [GO:0035435],

Molecular Function:
metalloendopeptidase activity [GO:0004222],
integrin binding [GO:0005178],
heparin binding [GO:0008201],
metallopeptidase activity [GO:0008237],
zinc ion binding [GO:0008270],
low-affinity phosphate transmembrane transporter activity [GO:0009673],
peptidase activity [GO:0008233],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
extracellular matrix [GO:0031012],
extracellular region [GO:0005576],