ADAM metallopeptidase with thrombospondin type 1 motif 7

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Li Fraumeni Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
extracellular matrix organization [GO:0030198],
negative regulation of chondrocyte differentiation [GO:0032331],
proteolysis involved in cellular protein catabolic process [GO:0051603],
cellular response to interleukin-1 [GO:0071347],
cellular response to tumor necrosis factor [GO:0071356],
cellular response to BMP stimulus [GO:0071773],
proteolysis [GO:0006508],

Molecular Function:
metalloendopeptidase activity [GO:0004222],
protein binding [GO:0005515],
metallopeptidase activity [GO:0008237],
metal ion binding [GO:0046872],
peptidase activity [GO:0008233],
hydrolase activity [GO:0016787],

Cellular Component:
extracellular region [GO:0005576],
endoplasmic reticulum lumen [GO:0005788],
cell surface [GO:0009986],
extracellular matrix [GO:0031012],