ADAM metallopeptidase with thrombospondin type 1 motif 5

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28728848 Primary chondrocytes derived from cartillage Human NO
31823179 Primary chondrocytes derived from cartillage Rat NO
31852919 Intervertebral disc Mouse NO
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
proteolysis [GO:0006508],
extracellular matrix disassembly [GO:0022617],
extracellular matrix organization [GO:0030198],
defense response to bacterium [GO:0042742],
tooth eruption [GO:0044691],

Molecular Function:
metalloendopeptidase activity [GO:0004222],
integrin binding [GO:0005178],
protein binding [GO:0005515],
heparin binding [GO:0008201],
peptidase activity [GO:0008233],
metallopeptidase activity [GO:0008237],
zinc ion binding [GO:0008270],
extracellular matrix binding [GO:0050840],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
endoplasmic reticulum lumen [GO:0005788],
extracellular matrix [GO:0031012],