ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif 5
Link to human orthologLink to mouse ortholog
Search for interactions with genes linked to senescence.
Status in senescence: Up-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 28728848 | Primary chondrocytes derived from cartillage | Human | NO | |
| 31823179 | Primary chondrocytes derived from cartillage | Rat | NO | |
| 31852919 | Intervertebral disc | Mouse | NO | |
| 31945125 | Primary astrocytes derived from brain | Human | YES | |
| 32622876 | Primary chondrocytes derived from cartilage | Human | No | |
| 32972203 | heartDPI14 vs healthy | Endothelial cell | Mouse | NO |
Status in senescence: Down-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 32611834 | Cartilage | Human | NO | |
GO terms:
Biological Process:
proteolysis [GO:0006508],
extracellular matrix disassembly [GO:0022617],
extracellular matrix organization [GO:0030198],
defense response to bacterium [GO:0042742],
tooth eruption [GO:0044691],
Molecular Function:
metalloendopeptidase activity [GO:0004222],
integrin binding [GO:0005178],
protein binding [GO:0005515],
heparin binding [GO:0008201],
peptidase activity [GO:0008233],
metallopeptidase activity [GO:0008237],
zinc ion binding [GO:0008270],
extracellular matrix binding [GO:0050840],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],
Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
endoplasmic reticulum lumen [GO:0005788],
extracellular matrix [GO:0031012],