ADAM metallopeptidase with thrombospondin type 1 motif 4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30900385 Intervertebral disc Mouse NO
31823179 Primary chondrocytes derived from cartillage Rat NO
32527988 Intervertebraldisc Mouse NO

GO terms:

Biological Process:
skeletal system development [GO:0001501],
proteolysis [GO:0006508],
extracellular matrix disassembly [GO:0022617],
extracellular matrix organization [GO:0030198],
defense response to bacterium [GO:0042742],

Molecular Function:
protease binding [GO:0002020],
metalloendopeptidase activity [GO:0004222],
protein binding [GO:0005515],
peptidase activity [GO:0008233],
metallopeptidase activity [GO:0008237],
metal ion binding [GO:0046872],
hydrolase activity [GO:0016787],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
nuclear speck [GO:0016607],
extracellular matrix [GO:0031012],