ADAM metallopeptidase with thrombospondin type 1 motif 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES
31945054 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES
32029712 Primary synovial fibroblast Human YES

GO terms:

Biological Process:
in utero embryonic development [GO:0001701],
vascular endothelial growth factor production [GO:0010573],
protein processing [GO:0016485],
extracellular matrix organization [GO:0030198],
collagen fibril organization [GO:0030199],
collagen catabolic process [GO:0030574],
collagen biosynthetic process [GO:0032964],
fibril organization [GO:0097435],
positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748],

Molecular Function:
endopeptidase activity [GO:0004175],
metalloendopeptidase activity [GO:0004222],
protein binding [GO:0005515],
heparin binding [GO:0008201],
zinc ion binding [GO:0008270],
peptidase activity [GO:0008233],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
extracellular matrix [GO:0031012],
extracellular exosome [GO:0070062],