ADAMTS3
ADAM metallopeptidase with thrombospondin type 1 motif 3
Link to human orthologLink to mouse ortholog
Search for interactions with genes linked to senescence.
Status in senescence: Up-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 29548335 | Saos-2 | Human | YES | |
| 31945054 | IMR-90 | Human | YES | |
Status in senescence: Down-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 31945125 | Primary astrocytes derived from brain | Human | YES | |
| 32029712 | Primary synovial fibroblast | Human | YES | |
GO terms:
Biological Process:
in utero embryonic development [GO:0001701],
vascular endothelial growth factor production [GO:0010573],
protein processing [GO:0016485],
extracellular matrix organization [GO:0030198],
collagen fibril organization [GO:0030199],
collagen catabolic process [GO:0030574],
collagen biosynthetic process [GO:0032964],
fibril organization [GO:0097435],
positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748],
Molecular Function:
endopeptidase activity [GO:0004175],
metalloendopeptidase activity [GO:0004222],
protein binding [GO:0005515],
heparin binding [GO:0008201],
zinc ion binding [GO:0008270],
peptidase activity [GO:0008233],
Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
extracellular matrix [GO:0031012],
extracellular exosome [GO:0070062],