ADAM metallopeptidase with thrombospondin type 1 motif 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
32029712 Primary synovial fibroblast Human YES
33296652 heart heart Human NO

GO terms:

Biological Process:
spermatogenesis [GO:0007283],
protein processing [GO:0016485],
extracellular matrix organization [GO:0030198],
collagen fibril organization [GO:0030199],
lung development [GO:0030324],
collagen catabolic process [GO:0030574],
skin development [GO:0043588],
proteolysis [GO:0006508],

Molecular Function:
metalloendopeptidase activity [GO:0004222],
metallopeptidase activity [GO:0008237],
zinc ion binding [GO:0008270],
peptidase activity [GO:0008233],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
extracellular region [GO:0005576],
extracellular matrix [GO:0031012],