CDK7

cyclin dependent kinase 7

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079],
G1/S transition of mitotic cell cycle [GO:0000082],
G2/M transition of mitotic cell cycle [GO:0000086],
transcription-coupled nucleotide-excision repair [GO:0006283],
nucleotide-excision repair, preincision complex assembly [GO:0006294],
transcription initiation from RNA polymerase I promoter [GO:0006361],
transcription elongation from RNA polymerase I promoter [GO:0006362],
termination of RNA polymerase I transcription [GO:0006363],
transcription from RNA polymerase II promoter [GO:0006366],
transcription initiation from RNA polymerase II promoter [GO:0006367],
transcription elongation from RNA polymerase II promoter [GO:0006368],
7-methylguanosine mRNA capping [GO:0006370],
protein phosphorylation [GO:0006468],
cell cycle arrest [GO:0007050],
androgen receptor signaling pathway [GO:0030521],
snRNA transcription from RNA polymerase II promoter [GO:0042795],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
protein stabilization [GO:0050821],
cell division [GO:0051301],
phosphorylation of RNA polymerase II C-terminal domain [GO:0070816],
DNA repair [GO:0006281],
cellular response to DNA damage stimulus [GO:0006974],
cell cycle [GO:0007049],
phosphorylation [GO:0016310],

Molecular Function:
transcription coactivator activity [GO:0003713],
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
cyclin-dependent protein serine/threonine kinase activity [GO:0004693],
protein binding [GO:0005515],
ATP binding [GO:0005524],
protein C-terminus binding [GO:0008022],
DNA-dependent ATPase activity [GO:0008094],
RNA polymerase II carboxy-terminal domain kinase activity [GO:0008353],
kinase activity [GO:0016301],
androgen receptor binding [GO:0050681],
nucleotide binding [GO:0000166],
transferase activity [GO:0016740],
macromolecular complex binding [GO:0044877],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
holo TFIIH complex [GO:0005675],
cytoplasm [GO:0005737],
cyclin-dependent protein kinase activating kinase holoenzyme complex [GO:0019907],
perinuclear region of cytoplasm [GO:0048471],
TFIIK complex [GO:0070985],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
membrane [GO:0016020],