cyclin dependent kinase 5 regulatory subunit 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES
31636448 HT-22 Mouse NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES
32029712 Primary synovial fibroblast Human YES

GO terms:

Biological Process:
regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079],
microtubule cytoskeleton organization [GO:0000226],
neuron migration [GO:0001764],
neuron cell-cell adhesion [GO:0007158],
G-protein coupled acetylcholine receptor signaling pathway [GO:0007213],
axon guidance [GO:0007411],
axonal fasciculation [GO:0007413],
brain development [GO:0007420],
embryo development ending in birth or egg hatching [GO:0009792],
regulation of macroautophagy [GO:0016241],
peptidyl-serine phosphorylation [GO:0018105],
peptidyl-threonine phosphorylation [GO:0018107],
cerebellum development [GO:0021549],
superior olivary nucleus maturation [GO:0021722],
hippocampus development [GO:0021766],
layer formation in cerebral cortex [GO:0021819],
neuron differentiation [GO:0030182],
negative regulation of axon extension [GO:0030517],
positive regulation of microtubule polymerization [GO:0031116],
neuron projection development [GO:0031175],
activation of protein kinase activity [GO:0032147],
regulation of actin cytoskeleton organization [GO:0032956],
ionotropic glutamate receptor signaling pathway [GO:0035235],
serine phosphorylation of STAT protein [GO:0042501],
positive regulation of neuron apoptotic process [GO:0043525],
regulation of neuron differentiation [GO:0045664],
positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737],
negative regulation of transcription, DNA-templated [GO:0045892],
ephrin receptor signaling pathway [GO:0048013],
rhythmic process [GO:0048511],
regulation of dendritic spine morphogenesis [GO:0061001],
positive regulation of cell cycle arrest [GO:0071158],
positive regulation of protein targeting to membrane [GO:0090314],
regulation of signal transduction by p53 class mediator [GO:1901796],
positive regulation of receptor biosynthetic process [GO:0010870],
cerebral cortex radially oriented cell migration [GO:0021799],
positive regulation of MHC class II biosynthetic process [GO:0045348],
positive regulation of protein kinase activity [GO:0045860],
regulation of microtubule cytoskeleton organization [GO:0070507],

Molecular Function:
protease binding [GO:0002020],
protein kinase activity [GO:0004672],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
kinase activity [GO:0016301],
protein kinase binding [GO:0019901],
protein kinase activator activity [GO:0030295],
ionotropic glutamate receptor binding [GO:0035255],
alpha-tubulin binding [GO:0043014],
protein serine/threonine kinase activator activity [GO:0043539],
cadherin binding [GO:0045296],
ephrin receptor binding [GO:0046875],
beta-tubulin binding [GO:0048487],
actin filament binding [GO:0051015],
cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575],
actin binding [GO:0003779],
cytoskeletal protein binding [GO:0008092],
Hsp90 protein binding [GO:0051879],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
postsynaptic density [GO:0014069],
membrane [GO:0016020],
cyclin-dependent protein kinase 5 holoenzyme complex [GO:0016533],
axon [GO:0030424],
dendrite [GO:0030425],
growth cone [GO:0030426],
neuromuscular junction [GO:0031594],
neuron projection [GO:0043005],
neuronal cell body [GO:0043025],
dendritic spine [GO:0043197],
perikaryon [GO:0043204],
intracellular membrane-bounded organelle [GO:0043231],
contractile fiber [GO:0043292],
perinuclear region of cytoplasm [GO:0048471],
presynapse [GO:0098793],
cell projection [GO:0042995],