CDK5

cyclin dependent kinase 5

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
22753194 Primary aortic endothelial cells from heart Pig NO
29321003 Primary bronchial epithelial cells derived from lung Human YES
31636448 HT-22 Mouse NO

GO terms:

Biological Process:
regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083],
microtubule cytoskeleton organization [GO:0000226],
neuron migration [GO:0001764],
synaptic transmission, dopaminergic [GO:0001963],
protein phosphorylation [GO:0006468],
intracellular protein transport [GO:0006886],
nucleocytoplasmic transport [GO:0006913],
mitochondrion organization [GO:0007005],
cell-matrix adhesion [GO:0007160],
chemical synaptic transmission [GO:0007268],
axonogenesis [GO:0007409],
synapse assembly [GO:0007416],
skeletal muscle tissue development [GO:0007519],
motor neuron axon guidance [GO:0008045],
visual learning [GO:0008542],
response to wounding [GO:0009611],
Schwann cell development [GO:0014044],
synaptic vesicle exocytosis [GO:0016079],
regulation of macroautophagy [GO:0016241],
phosphorylation [GO:0016310],
histone phosphorylation [GO:0016572],
peptidyl-serine phosphorylation [GO:0018105],
peptidyl-threonine phosphorylation [GO:0018107],
sensory perception of pain [GO:0019233],
cerebellar cortex formation [GO:0021697],
hippocampus development [GO:0021766],
layer formation in cerebral cortex [GO:0021819],
central nervous system neuron development [GO:0021954],
corpus callosum development [GO:0022038],
neuron differentiation [GO:0030182],
regulation of cell migration [GO:0030334],
negative regulation of axon extension [GO:0030517],
cortical actin cytoskeleton organization [GO:0030866],
neuron projection development [GO:0031175],
negative regulation of protein ubiquitination [GO:0031397],
negative regulation of synaptic plasticity [GO:0031914],
positive regulation of protein binding [GO:0032092],
receptor catabolic process [GO:0032801],
positive regulation of glial cell apoptotic process [GO:0034352],
synaptic transmission, glutamatergic [GO:0035249],
protein localization to synapse [GO:0035418],
serine phosphorylation of STAT protein [GO:0042501],
regulation of apoptotic process [GO:0042981],
receptor clustering [GO:0043113],
positive regulation of neuron apoptotic process [GO:0043525],
negative regulation of cell cycle [GO:0045786],
positive regulation of protein kinase activity [GO:0045860],
negative regulation of proteolysis [GO:0045861],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of calcium ion-dependent exocytosis [GO:0045956],
protein autophosphorylation [GO:0046777],
negative regulation of protein export from nucleus [GO:0046826],
behavioral response to cocaine [GO:0048148],
regulation of synaptic plasticity [GO:0048167],
synaptic vesicle endocytosis [GO:0048488],
synaptic vesicle transport [GO:0048489],
rhythmic process [GO:0048511],
axon extension [GO:0048675],
oligodendrocyte differentiation [GO:0048709],
dendrite morphogenesis [GO:0048813],
cell division [GO:0051301],
neuron apoptotic process [GO:0051402],
regulation of synaptic transmission, glutamatergic [GO:0051966],
excitatory postsynaptic potential [GO:0060079],
regulation of dendritic spine morphogenesis [GO:0061001],
calcium ion import [GO:0070509],
regulation of cell cycle arrest [GO:0071156],
positive regulation of protein targeting to membrane [GO:0090314],
synapse disassembly [GO:0098883],
regulation of neurotransmitter receptor activity [GO:0099601],
induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration [GO:0099703],
negative regulation of neuron death [GO:1901215],
positive regulation of voltage-gated calcium channel activity [GO:1901387],
regulation of signal transduction by p53 class mediator [GO:1901796],
regulation of protein localization to plasma membrane [GO:1903076],
regulation of synaptic vesicle recycling [GO:1903421],
cellular response to beta-amyloid [GO:1904646],
positive regulation of actin cytoskeleton reorganization [GO:2000251],
positive regulation of protein phosphorylation [GO:0001934],
exocytosis [GO:0006887],
apoptotic process [GO:0006915],
cell cycle [GO:0007049],
nervous system development [GO:0007399],
associative learning [GO:0008306],
cell migration [GO:0016477],
telencephalon development [GO:0021537],
cerebellum development [GO:0021549],
cerebellar cortex development [GO:0021695],
cerebral cortex development [GO:0021987],
forebrain development [GO:0030900],
response to cocaine [GO:0042220],
regulated exocytosis [GO:0045055],
neuron projection morphogenesis [GO:0048812],
regulation of postsynaptic membrane potential [GO:0060078],
positive regulation of presynaptic cytosolic calcium concentration [GO:0099533],
positive regulation of neuron death [GO:1901216],

Molecular Function:
p53 binding [GO:0002039],
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
cyclin-dependent protein serine/threonine kinase activity [GO:0004693],
ErbB-2 class receptor binding [GO:0005176],
protein binding [GO:0005515],
ATP binding [GO:0005524],
microtubule binding [GO:0008017],
kinase activity [GO:0016301],
protein kinase binding [GO:0019901],
acetylcholine receptor activator activity [GO:0030549],
ErbB-3 class receptor binding [GO:0043125],
ephrin receptor binding [GO:0046875],
tau protein binding [GO:0048156],
tau-protein kinase activity [GO:0050321],
Hsp90 protein binding [GO:0051879],
voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels [GO:0099635],
nucleotide binding [GO:0000166],
cytoskeletal protein binding [GO:0008092],
transferase activity [GO:0016740],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
microtubule [GO:0005874],
plasma membrane [GO:0005886],
postsynaptic density [GO:0014069],
membrane [GO:0016020],
cyclin-dependent protein kinase 5 holoenzyme complex [GO:0016533],
lamellipodium [GO:0030027],
filopodium [GO:0030175],
axon [GO:0030424],
dendrite [GO:0030425],
growth cone [GO:0030426],
neuromuscular junction [GO:0031594],
neuron projection [GO:0043005],
neuronal cell body [GO:0043025],
perikaryon [GO:0043204],
presynapse [GO:0098793],
glutamatergic synapse [GO:0098978],
nucleolus [GO:0005730],
cytoskeleton [GO:0005856],
cell junction [GO:0030054],
cell projection [GO:0042995],
synapse [GO:0045202],
postsynapse [GO:0098794],