CDK2

cyclin dependent kinase 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
23316279 MEF Mouse NO
28345297 RPE, U2OS Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
10791951 Primary fibroblasts derived from mouse embryo f Mouse NO
15922732 HUVEC Human NO
19966300 REF, HeLa, U2OS and U-937 cells human NO
20010815 MEF Mouse NO
24876127 HEK 293T, MEF, primary fibroblasts derived from foreskin Human, mouse NO
25149358 BJ, MEF Human, mouse NO
31148378 MRC-5 Human YES
31503005 MEF Mouse NO
31578521 Huh-7 Human YES
31632967 Primary hematopoietic stem cells derived from bone marrow Mouse NO
31646843 Primary astrocytes derived from rat Rat NO
31860636 2BS, 293T  Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
G1/S transition of mitotic cell cycle [GO:0000082],
G2/M transition of mitotic cell cycle [GO:0000086],
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
DNA replication [GO:0006260],
DNA repair [GO:0006281],
protein phosphorylation [GO:0006468],
potassium ion transport [GO:0006813],
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977],
centriole replication [GO:0007099],
Ras protein signal transduction [GO:0007265],
positive regulation of cell proliferation [GO:0008284],
regulation of G2/M transition of mitotic cell cycle [GO:0010389],
regulation of gene expression [GO:0010468],
histone phosphorylation [GO:0016572],
peptidyl-serine phosphorylation [GO:0018105],
anaphase-promoting complex-dependent catabolic process [GO:0031145],
mitotic G1 DNA damage checkpoint [GO:0031571],
positive regulation of DNA-dependent DNA replication initiation [GO:0032298],
positive regulation of transcription, DNA-templated [GO:0045893],
centrosome duplication [GO:0051298],
cell division [GO:0051301],
meiotic cell cycle [GO:0051321],
regulation of gene silencing [GO:0060968],
cellular response to nitric oxide [GO:0071732],
regulation of signal transduction by p53 class mediator [GO:1901796],
cellular response to DNA damage stimulus [GO:0006974],
cell cycle [GO:0007049],
phosphorylation [GO:0016310],
cellular response to insulin stimulus [GO:0032869],
response to cAMP [GO:0051591],
response to electrical stimulus [GO:0051602],

Molecular Function:
magnesium ion binding [GO:0000287],
protein serine/threonine kinase activity [GO:0004674],
cyclin-dependent protein serine/threonine kinase activity [GO:0004693],
protein binding [GO:0005515],
ATP binding [GO:0005524],
protein domain specific binding [GO:0019904],
cyclin binding [GO:0030332],
histone kinase activity [GO:0035173],
cyclin-dependent protein kinase activity [GO:0097472],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
macromolecular complex binding [GO:0044877],
metal ion binding [GO:0046872],

Cellular Component:
cyclin-dependent protein kinase holoenzyme complex [GO:0000307],
chromosome, telomeric region [GO:0000781],
condensed chromosome [GO:0000793],
X chromosome [GO:0000805],
Y chromosome [GO:0000806],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
transcription factor complex [GO:0005667],
cytoplasm [GO:0005737],
endosome [GO:0005768],
centrosome [GO:0005813],
cytosol [GO:0005829],
Cajal body [GO:0015030],
cyclin A1-CDK2 complex [GO:0097123],
cyclin A2-CDK2 complex [GO:0097124],
cyclin E1-CDK2 complex [GO:0097134],
cyclin E2-CDK2 complex [GO:0097135],
cytoskeleton [GO:0005856],
intracellular membrane-bounded organelle [GO:0043231],