ADAM metallopeptidase with thrombospondin type 1 motif 15

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Saos-2 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES
32029712 Primary synovial fibroblast Human YES

GO terms:

Biological Process:
proteolysis [GO:0006508],
extracellular matrix organization [GO:0030198],

Molecular Function:
metalloendopeptidase activity [GO:0004222],
heparin binding [GO:0008201],
zinc ion binding [GO:0008270],
extracellular matrix binding [GO:0050840],
endopeptidase activity [GO:0004175],
peptidase activity [GO:0008233],
metallopeptidase activity [GO:0008237],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
extracellular space [GO:0005615],
cell surface [GO:0009986],
extracellular matrix [GO:0031012],
extracellular region [GO:0005576],