CDK1

cyclin dependent kinase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28345297 RPE, U2OS Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
26687548 IDH4 Human NO
29321003 Primary bronchial epithelial cells derived from lung Human YES
29449545 HMECs, MRC5, IMR-90, GP293, WI-38, HUVEC Human NO
29548335 Saos-2, Li-Fraumeni Human YES
30920150 Primary vascular progenitor cells derived from artery Human YES
30987592 MCF7 Breast Human YES
30988157 IMR-90 Human YES
31148378 MRC-5 Human YES
31578521 Huh-7 Human YES
31586152 HUVEC Human NO
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
G2/M transition of mitotic cell cycle [GO:0000086],
activation of MAPK activity [GO:0000187],
microtubule cytoskeleton organization [GO:0000226],
DNA replication [GO:0006260],
DNA repair [GO:0006281],
transcription initiation from RNA polymerase II promoter [GO:0006367],
protein phosphorylation [GO:0006468],
apoptotic process [GO:0006915],
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977],
mitotic nuclear envelope disassembly [GO:0007077],
mitotic G2 DNA damage checkpoint [GO:0007095],
centrosome cycle [GO:0007098],
pronuclear fusion [GO:0007344],
cell aging [GO:0007569],
cell proliferation [GO:0008283],
regulation of G2/M transition of mitotic cell cycle [GO:0010389],
positive regulation of gene expression [GO:0010628],
positive regulation of G2/M transition of mitotic cell cycle [GO:0010971],
regulation of Schwann cell differentiation [GO:0014038],
response to organic cyclic compound [GO:0014070],
response to amine [GO:0014075],
response to activity [GO:0014823],
cell migration [GO:0016477],
histone phosphorylation [GO:0016572],
protein deubiquitination [GO:0016579],
peptidyl-serine phosphorylation [GO:0018105],
peptidyl-threonine phosphorylation [GO:0018107],
chromosome condensation [GO:0030261],
epithelial cell differentiation [GO:0030855],
animal organ regeneration [GO:0031100],
anaphase-promoting complex-dependent catabolic process [GO:0031145],
protein localization to kinetochore [GO:0034501],
positive regulation of protein import into nucleus [GO:0042307],
regulation of circadian rhythm [GO:0042752],
negative regulation of apoptotic process [GO:0043066],
response to ethanol [GO:0045471],
positive regulation of DNA replication [GO:0045740],
regulation of embryonic development [GO:0045995],
response to cadmium ion [GO:0046686],
response to copper ion [GO:0046688],
viral entry into host cell [GO:0046718],
rhythmic process [GO:0048511],
response to axon injury [GO:0048678],
cell division [GO:0051301],
ventricular cardiac muscle cell development [GO:0055015],
positive regulation of cardiac muscle cell proliferation [GO:0060045],
macromolecular complex assembly [GO:0065003],
cellular response to hydrogen peroxide [GO:0070301],
Golgi disassembly [GO:0090166],
ciliary basal body docking [GO:0097711],
positive regulation of protein localization to nucleus [GO:1900182],
regulation of mitotic cell cycle phase transition [GO:1901990],
positive regulation of mitochondrial ATP synthesis coupled electron transport [GO:1905448],
cell cycle [GO:0007049],
response to organonitrogen compound [GO:0010243],
phosphorylation [GO:0016310],
mitotic cell cycle phase transition [GO:0044772],
positive regulation of mitotic cell cycle [GO:0045931],

Molecular Function:
virus receptor activity [GO:0001618],
chromatin binding [GO:0003682],
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
cyclin-dependent protein serine/threonine kinase activity [GO:0004693],
protein binding [GO:0005515],
ATP binding [GO:0005524],
RNA polymerase II carboxy-terminal domain kinase activity [GO:0008353],
cyclin binding [GO:0030332],
Hsp70 protein binding [GO:0030544],
histone kinase activity [GO:0035173],
cyclin-dependent protein kinase activity [GO:0097472],
nucleotide binding [GO:0000166],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
cyclin-dependent protein kinase holoenzyme complex [GO:0000307],
nuclear chromosome, telomeric region [GO:0000784],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
mitochondrial matrix [GO:0005759],
endoplasmic reticulum membrane [GO:0005789],
centrosome [GO:0005813],
cytosol [GO:0005829],
spindle microtubule [GO:0005876],
membrane [GO:0016020],
midbody [GO:0030496],
extracellular exosome [GO:0070062],
mitotic spindle [GO:0072686],
cyclin B1-CDK1 complex [GO:0097125],
cytoskeleton [GO:0005856],