cadherin 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2, Li-Fraumeni Human YES
31148378 MRC-5 Human YES
33297115 A549 Human No

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29257288 Primary cells derived from nucleus pulposus Rat NO
29768261 Primary cells derived from nucleus pulposus Rat NO

GO terms:

Biological Process:
cell adhesion [GO:0007155],
homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156],
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157],
synapse assembly [GO:0007416],
brain development [GO:0007420],
glial cell differentiation [GO:0010001],
cell migration [GO:0016477],
cerebral cortex development [GO:0021987],
adherens junction organization [GO:0034332],
positive regulation of MAPK cascade [GO:0043410],
post-translational protein modification [GO:0043687],
cellular protein metabolic process [GO:0044267],
cell-cell adhesion mediated by cadherin [GO:0044331],
blood vessel morphogenesis [GO:0048514],
brain morphogenesis [GO:0048854],
homeostasis of number of cells [GO:0048872],
regulation of axonogenesis [GO:0050770],
striated muscle cell differentiation [GO:0051146],
positive regulation of muscle cell differentiation [GO:0051149],
regulation of synaptic transmission, glutamatergic [GO:0051966],
radial glial cell differentiation [GO:0060019],
neuroepithelial cell differentiation [GO:0060563],
regulation of oligodendrocyte progenitor proliferation [GO:0070445],
protein localization to plasma membrane [GO:0072659],
negative regulation of canonical Wnt signaling pathway [GO:0090090],
neuroligin clustering involved in postsynaptic membrane assembly [GO:0097118],
neuronal stem cell population maintenance [GO:0097150],
cell-cell adhesion [GO:0098609],
cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742],
regulation of postsynaptic density protein 95 clustering [GO:1902897],
positive regulation of synaptic vesicle clustering [GO:2000809],
regulation of signal transduction [GO:0009966],
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339],
telencephalon development [GO:0021537],
regulation of myelination [GO:0031641],
regulation of protein localization [GO:0032880],
regulation of Rho protein signal transduction [GO:0035023],
modulation of synaptic transmission [GO:0050804],

Molecular Function:
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
beta-catenin binding [GO:0008013],
protein kinase binding [GO:0019901],
protein phosphatase binding [GO:0019903],
identical protein binding [GO:0042802],
alpha-catenin binding [GO:0045294],
gamma-catenin binding [GO:0045295],
cadherin binding [GO:0045296],
enzyme binding [GO:0019899],
macromolecular complex binding [GO:0044877],
metal ion binding [GO:0046872],
nitric-oxide synthase binding [GO:0050998],

Cellular Component:
cytoplasm [GO:0005737],
endoplasmic reticulum lumen [GO:0005788],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
cell-cell junction [GO:0005911],
adherens junction [GO:0005912],
fascia adherens [GO:0005916],
focal adhesion [GO:0005925],
cell surface [GO:0009986],
postsynaptic density [GO:0014069],
intercalated disc [GO:0014704],
basolateral plasma membrane [GO:0016323],
apical plasma membrane [GO:0016324],
catenin complex [GO:0016342],
lamellipodium [GO:0030027],
cell junction [GO:0030054],
cortical actin cytoskeleton [GO:0030864],
sarcolemma [GO:0042383],
neuron projection [GO:0043005],
plasma membrane raft [GO:0044853],
apical part of cell [GO:0045177],
integral component of presynaptic active zone membrane [GO:0099059],
integral component of postsynaptic specialization membrane [GO:0099060],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
apicolateral plasma membrane [GO:0016327],
T-tubule [GO:0030315],
macromolecular complex [GO:0032991],
synapse [GO:0045202],
glutamatergic synapse [GO:0098978],