ADAM metallopeptidase with thrombospondin type 1 motif 13

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
proteolysis [GO:0006508],
cell-matrix adhesion [GO:0007160],
integrin-mediated signaling pathway [GO:0007229],
glycoprotein metabolic process [GO:0009100],
response to toxic substance [GO:0009636],
response to amine [GO:0014075],
protein processing [GO:0016485],
platelet activation [GO:0030168],
extracellular matrix organization [GO:0030198],
response to potassium ion [GO:0035864],
peptide catabolic process [GO:0043171],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to interferon-gamma [GO:0071346],
cellular response to interleukin-4 [GO:0071353],
cellular response to tumor necrosis factor [GO:0071356],
blood coagulation [GO:0007596],
hemostasis [GO:0007599],

Molecular Function:
metalloendopeptidase activity [GO:0004222],
integrin binding [GO:0005178],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
metallopeptidase activity [GO:0008237],
zinc ion binding [GO:0008270],
endopeptidase activity [GO:0004175],
peptidase activity [GO:0008233],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
extracellular space [GO:0005615],
endoplasmic reticulum lumen [GO:0005788],
cell surface [GO:0009986],
extracellular matrix [GO:0031012],
extracellular region [GO:0005576],