ABAT

4-aminobutyrate aminotransferase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2, Li-Fraumeni Human YES
30987592 MCF7 Breast Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
response to hypoxia [GO:0001666],
aging [GO:0007568],
copulation [GO:0007620],
locomotory behavior [GO:0007626],
gamma-aminobutyric acid metabolic process [GO:0009448],
gamma-aminobutyric acid biosynthetic process [GO:0009449],
gamma-aminobutyric acid catabolic process [GO:0009450],
response to iron ion [GO:0010039],
negative regulation of gamma-aminobutyric acid secretion [GO:0014053],
cerebellum development [GO:0021549],
positive regulation of heat generation [GO:0031652],
positive regulation of insulin secretion [GO:0032024],
negative regulation of dopamine secretion [GO:0033602],
response to nicotine [GO:0035094],
exploration behavior [GO:0035640],
neurotransmitter catabolic process [GO:0042135],
response to ethanol [GO:0045471],
negative regulation of blood pressure [GO:0045776],
positive regulation of dopamine metabolic process [GO:0045964],
behavioral response to cocaine [GO:0048148],
positive regulation of uterine smooth muscle contraction [GO:0070474],
negative regulation of platelet aggregation [GO:0090331],
positive regulation of inhibitory postsynaptic potential [GO:0097151],
positive regulation of prolactin secretion [GO:1902722],
positive regulation of aspartate secretion [GO:1904450],
response to cocaine [GO:0042220],
response to drug [GO:0042493],

Molecular Function:
4-aminobutyrate transaminase activity [GO:0003867],
pyridoxal phosphate binding [GO:0030170],
succinate-semialdehyde dehydrogenase binding [GO:0032145],
4-aminobutyrate:2-oxoglutarate transaminase activity [GO:0034386],
identical protein binding [GO:0042802],
metal ion binding [GO:0046872],
(S)-3-amino-2-methylpropionate transaminase activity [GO:0047298],
iron-sulfur cluster binding [GO:0051536],
catalytic activity [GO:0003824],
transaminase activity [GO:0008483],
transferase activity [GO:0016740],

Cellular Component:
mitochondrion [GO:0005739],
mitochondrial matrix [GO:0005759],
4-aminobutyrate transaminase complex [GO:0032144],
neuron projection [GO:0043005],