CDC5L

cell division cycle 5 like

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES
31983656 MSC Human YES

GO terms:

Biological Process:
mitotic cell cycle [GO:0000278],
mRNA splicing, via spliceosome [GO:0000398],
DNA repair [GO:0006281],
cellular response to fibroblast growth factor stimulus [GO:0044344],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
cellular response to interleukin-2 [GO:0071352],
signal transduction involved in DNA damage checkpoint [GO:0072422],
cellular response to wortmannin [GO:1904568],
cellular response to nerve growth factor stimulus [GO:1990090],
cellular response to prolactin [GO:1990646],
mRNA processing [GO:0006397],
cellular response to DNA damage stimulus [GO:0006974],
cell cycle [GO:0007049],
RNA splicing [GO:0008380],

Molecular Function:
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
transcription corepressor binding [GO:0001222],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
DNA binding [GO:0003677],
RNA binding [GO:0003723],
protein binding [GO:0005515],
protein phosphatase 1 binding [GO:0008157],
protein kinase binding [GO:0019901],
leucine zipper domain binding [GO:0043522],
WD40-repeat domain binding [GO:0071987],

Cellular Component:
Prp19 complex [GO:0000974],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
DNA replication factor A complex [GO:0005662],
cytoplasm [GO:0005737],
membrane [GO:0016020],
nuclear speck [GO:0016607],
perinuclear region of cytoplasm [GO:0048471],
U2-type catalytic step 2 spliceosome [GO:0071007],
catalytic step 2 spliceosome [GO:0071013],
spliceosomal complex [GO:0005681],
protein-DNA complex [GO:0032993],