ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif 1
Link to human orthologLink to mouse ortholog
Search for interactions with genes linked to senescence.
Status in senescence: Up-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 31945125 | Primary astrocytes derived from brain | Human | YES | |
Status in senescence: Down-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 29548335 | Li Fraumeni | Human | YES | |
| 31983656 | MSC | Human | YES | |
| 32029712 | Primary synovial fibroblast | Human | YES | |
GO terms:
Biological Process:
ovulation from ovarian follicle [GO:0001542],
kidney development [GO:0001822],
proteolysis [GO:0006508],
integrin-mediated signaling pathway [GO:0007229],
negative regulation of cell proliferation [GO:0008285],
negative regulation of angiogenesis [GO:0016525],
extracellular matrix organization [GO:0030198],
heart trabecula formation [GO:0060347],
positive regulation of G1/S transition of mitotic cell cycle [GO:1900087],
positive regulation of vascular smooth muscle cell proliferation [GO:1904707],
positive regulation of vascular associated smooth muscle cell migration [GO:1904754],
positive regulation of neuron projection development [GO:0010976],
Molecular Function:
metalloendopeptidase activity [GO:0004222],
heparin binding [GO:0008201],
metallopeptidase activity [GO:0008237],
zinc ion binding [GO:0008270],
protein binding [GO:0005515],
peptidase activity [GO:0008233],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],
Cellular Component:
basement membrane [GO:0005604],
extracellular matrix [GO:0031012],
cytoplasmic vesicle [GO:0031410],
extracellular region [GO:0005576],