ADAM metallopeptidase domain 8

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
cell morphogenesis [GO:0000902],
angiogenesis [GO:0001525],
leukocyte migration involved in inflammatory response [GO:0002523],
positive regulation of acute inflammatory response [GO:0002675],
proteolysis [GO:0006508],
inflammatory response [GO:0006954],
positive regulation of protein processing [GO:0010954],
regulation of cell-cell adhesion [GO:0022407],
extracellular matrix disassembly [GO:0022617],
positive regulation of T cell differentiation in thymus [GO:0033089],
neutrophil degranulation [GO:0043312],
positive regulation of MAP kinase activity [GO:0043406],
negative regulation of neuron apoptotic process [GO:0043524],
positive regulation of innate immune response [GO:0045089],
positive regulation of bone resorption [GO:0045780],
positive regulation of cell adhesion [GO:0045785],
lymphocyte chemotaxis [GO:0048247],
positive regulation of protein secretion [GO:0050714],
positive regulation of membrane protein ectodomain proteolysis [GO:0051044],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
positive regulation of protein kinase B signaling [GO:0051897],
positive regulation of thymocyte apoptotic process [GO:0070245],
cellular response to hypoxia [GO:0071456],
cell-cell adhesion [GO:0098609],
positive regulation of tumor necrosis factor (ligand) superfamily member 11 production [GO:2000309],
positive regulation of neutrophil extravasation [GO:2000391],
positive regulation of fibronectin-dependent thymocyte migration [GO:2000415],
positive regulation of eosinophil migration [GO:2000418],
positive regulation of cellular extravasation [GO:0002693],
cell-matrix adhesion [GO:0007160],
blood vessel endothelial cell migration [GO:0043534],
regulation of osteoclast differentiation [GO:0045670],
tissue morphogenesis [GO:0048729],
positive regulation of inflammatory response [GO:0050729],
membrane fusion [GO:0061025],
osteoclast fusion [GO:0072675],
negative regulation of thymocyte aggregation [GO:2000399],
positive regulation of T cell migration [GO:2000406],

Molecular Function:
metalloendopeptidase activity [GO:0004222],
serine-type endopeptidase activity [GO:0004252],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
metallopeptidase activity [GO:0008237],
zinc ion binding [GO:0008270],
protein self-association [GO:0043621],
cell adhesion molecule binding [GO:0050839],
integrin binding [GO:0005178],
peptidase activity [GO:0008233],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
podosome [GO:0002102],
cytoplasm [GO:0005737],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
cell surface [GO:0009986],
phagolysosome [GO:0032010],
dense core granule membrane [GO:0032127],
specific granule membrane [GO:0035579],
specific granule [GO:0042581],
tertiary granule [GO:0070820],
tertiary granule membrane [GO:0070821],
alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex [GO:0071065],
alpha9-beta1 integrin-ADAM8 complex [GO:0071133],
ficolin-1-rich granule membrane [GO:0101003],
membrane [GO:0016020],
integral component of membrane [GO:0016021],