CDC42

cell division cycle 42

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
18325348 IMR-90 Human NO
25057989 HUVEC Lung, Aorta, Kidney Human, mouse, worm NO
29804242 Primary mesenchymal stem cells derive from adipose tissue Rat NO

GO terms:

Biological Process:
sprouting angiogenesis [GO:0002040],
cardiac conduction system development [GO:0003161],
endocytosis [GO:0006897],
phagocytosis, engulfment [GO:0006911],
actin filament organization [GO:0007015],
Golgi organization [GO:0007030],
regulation of mitotic nuclear division [GO:0007088],
nuclear migration [GO:0007097],
establishment or maintenance of cell polarity [GO:0007163],
integrin-mediated signaling pathway [GO:0007229],
blood coagulation [GO:0007596],
regulation of lamellipodium assembly [GO:0010591],
positive regulation of lamellipodium assembly [GO:0010592],
cell migration [GO:0016477],
protein ubiquitination [GO:0016567],
substantia nigra development [GO:0021762],
cell projection assembly [GO:0030031],
actin cytoskeleton organization [GO:0030036],
macrophage differentiation [GO:0030225],
positive regulation of cell growth [GO:0030307],
positive regulation of pseudopodium assembly [GO:0031274],
T cell costimulation [GO:0031295],
negative regulation of protein complex assembly [GO:0031333],
positive regulation of cytokinesis [GO:0032467],
Cdc42 protein signal transduction [GO:0032488],
cell junction assembly [GO:0034329],
adherens junction organization [GO:0034332],
cellular protein localization [GO:0034613],
interleukin-12-mediated signaling pathway [GO:0035722],
dendritic cell migration [GO:0036336],
Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096],
neuropilin signaling pathway [GO:0038189],
viral RNA genome replication [GO:0039694],
negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059],
regulation of protein binding [GO:0043393],
positive regulation of neuron apoptotic process [GO:0043525],
positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552],
establishment of epithelial cell apical/basal polarity [GO:0045198],
positive regulation of DNA replication [GO:0045740],
positive regulation of JNK cascade [GO:0046330],
filopodium assembly [GO:0046847],
vascular endothelial growth factor receptor signaling pathway [GO:0048010],
ephrin receptor signaling pathway [GO:0048013],
positive regulation of pinocytosis [GO:0048549],
neuron fate determination [GO:0048664],
regulation of small GTPase mediated signal transduction [GO:0051056],
positive regulation of muscle cell differentiation [GO:0051149],
regulation of filopodium assembly [GO:0051489],
positive regulation of filopodium assembly [GO:0051491],
regulation of stress fiber assembly [GO:0051492],
positive regulation of stress fiber assembly [GO:0051496],
establishment of Golgi localization [GO:0051683],
positive regulation of synapse structural plasticity [GO:0051835],
regulation of attachment of spindle microtubules to kinetochore [GO:0051988],
heart contraction [GO:0060047],
Wnt signaling pathway, planar cell polarity pathway [GO:0060071],
positive regulation of epithelial cell proliferation involved in lung morphogenesis [GO:0060501],
submandibular salivary gland formation [GO:0060661],
dendritic spine morphogenesis [GO:0060997],
cellular response to interferon-gamma [GO:0071346],
organelle transport along microtubule [GO:0072384],
actin filament branching [GO:0090135],
positive regulation of intracellular protein transport [GO:0090316],
modification of synaptic structure [GO:0099563],
positive regulation of substrate adhesion-dependent cell spreading [GO:1900026],
positive regulation of actin cytoskeleton reorganization [GO:2000251],
small GTPase mediated signal transduction [GO:0007264],
Rho protein signal transduction [GO:0007266],
nervous system development [GO:0007399],
endosomal transport [GO:0016197],
cell differentiation [GO:0030154],
establishment or maintenance of apical/basal cell polarity [GO:0035088],
positive regulation of catalytic activity [GO:0043085],
positive regulation of MAPK cascade [GO:0043410],
nucleus localization [GO:0051647],
cell-cell adhesion [GO:0098609],

Molecular Function:
GTPase activity [GO:0003924],
protein binding [GO:0005515],
GTP binding [GO:0005525],
protein kinase binding [GO:0019901],
GTP-dependent protein binding [GO:0030742],
mitogen-activated protein kinase kinase kinase binding [GO:0031435],
thioesterase binding [GO:0031996],
GBD domain binding [GO:0032427],
apolipoprotein A-I receptor binding [GO:0034191],
identical protein binding [GO:0042802],
ubiquitin protein ligase activity [GO:0061630],
nucleotide binding [GO:0000166],
hydrolase activity [GO:0016787],
Rho GDP-dissociation inhibitor binding [GO:0051022],

Cellular Component:
Golgi membrane [GO:0000139],
storage vacuole [GO:0000322],
cytoplasm [GO:0005737],
endoplasmic reticulum membrane [GO:0005789],
centrosome [GO:0005813],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
cell-cell junction [GO:0005911],
focal adhesion [GO:0005925],
membrane [GO:0016020],
Golgi transport complex [GO:0017119],
secretory granule [GO:0030141],
filopodium [GO:0030175],
midbody [GO:0030496],
leading edge membrane [GO:0031256],
macromolecular complex [GO:0032991],
cytoplasmic ribonucleoprotein granule [GO:0036464],
neuron projection [GO:0043005],
neuronal cell body [GO:0043025],
dendritic spine [GO:0043197],
apical part of cell [GO:0045177],
phagocytic vesicle [GO:0045335],
spindle midzone [GO:0051233],
extracellular exosome [GO:0070062],
mitotic spindle [GO:0072686],
intracellular [GO:0005622],
cell projection [GO:0042995],
myelin sheath [GO:0043209],
cell periphery [GO:0071944],