ADAM metallopeptidase domain 23

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
31945054 IMR-90 Human YES

GO terms:

Biological Process:
proteolysis [GO:0006508],
cell adhesion [GO:0007155],
central nervous system development [GO:0007417],
cellular response to leukemia inhibitory factor [GO:1990830],

Molecular Function:
metalloendopeptidase activity [GO:0004222],
integrin binding [GO:0005178],
protein binding [GO:0005515],
metallopeptidase activity [GO:0008237],

Cellular Component:
extracellular region [GO:0005576],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
glutamatergic synapse [GO:0098978],
integral component of presynaptic membrane [GO:0099056],
membrane [GO:0016020],
integral component of membrane [GO:0016021],