ADAM metallopeptidase domain 22

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
proteolysis [GO:0006508],
adult locomotory behavior [GO:0008344],
Schwann cell differentiation [GO:0014037],
myelination in peripheral nervous system [GO:0022011],
gliogenesis [GO:0042063],
neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645],
cell adhesion [GO:0007155],
negative regulation of cell adhesion [GO:0007162],
central nervous system development [GO:0007417],

Molecular Function:
metalloendopeptidase activity [GO:0004222],
protein binding [GO:0005515],
metallopeptidase activity [GO:0008237],
integrin binding [GO:0005178],

Cellular Component:
plasma membrane [GO:0005886],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
axon [GO:0030424],
cell projection [GO:0042995],
glutamatergic synapse [GO:0098978],
integral component of postsynaptic density membrane [GO:0099061],