ADAM metallopeptidase domain 21

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
proteolysis [GO:0006508],
single fertilization [GO:0007338],
binding of sperm to zona pellucida [GO:0007339],

Molecular Function:
metalloendopeptidase activity [GO:0004222],
metallopeptidase activity [GO:0008237],
metal ion binding [GO:0046872],
peptidase activity [GO:0008233],
hydrolase activity [GO:0016787],

Cellular Component:
plasma membrane [GO:0005886],
integral component of membrane [GO:0016021],
axon [GO:0030424],
neuronal cell body [GO:0043025],
membrane [GO:0016020],
neuron projection [GO:0043005],