CD4

CD4 molecule

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

GO terms:

Biological Process:
cytokine production [GO:0001816],
positive regulation of protein phosphorylation [GO:0001934],
adaptive immune response [GO:0002250],
induction by virus of host cell-cell fusion [GO:0006948],
immune response [GO:0006955],
cell adhesion [GO:0007155],
signal transduction [GO:0007165],
cell surface receptor signaling pathway [GO:0007166],
enzyme linked receptor protein signaling pathway [GO:0007167],
transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169],
positive regulation of calcium ion transport into cytosol [GO:0010524],
fusion of virus membrane with host plasma membrane [GO:0019064],
cytokine-mediated signaling pathway [GO:0019221],
T cell differentiation [GO:0030217],
macrophage differentiation [GO:0030225],
response to estradiol [GO:0032355],
maintenance of protein location in cell [GO:0032507],
response to vitamin D [GO:0033280],
positive regulation of kinase activity [GO:0033674],
helper T cell enhancement of adaptive immune response [GO:0035397],
interleukin-15-mediated signaling pathway [GO:0035723],
positive regulation of T cell proliferation [GO:0042102],
T cell activation [GO:0042110],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
positive regulation of MAPK cascade [GO:0043410],
T cell selection [GO:0045058],
positive regulation of interleukin-2 biosynthetic process [GO:0045086],
positive regulation of monocyte differentiation [GO:0045657],
positive regulation of protein kinase activity [GO:0045860],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of viral entry into host cell [GO:0046598],
regulation of defense response to virus by virus [GO:0050690],
positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731],
defense response to Gram-negative bacterium [GO:0050829],
positive regulation of calcium-mediated signaling [GO:0050850],
T cell receptor signaling pathway [GO:0050852],
regulation of T cell activation [GO:0050863],
regulation of calcium ion transport [GO:0051924],
membrane organization [GO:0061024],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011],
immune system process [GO:0002376],
positive regulation of T cell activation [GO:0050870],

Molecular Function:
virus receptor activity [GO:0001618],
transmembrane signaling receptor activity [GO:0004888],
extracellular matrix structural constituent [GO:0005201],
protein binding [GO:0005515],
zinc ion binding [GO:0008270],
coreceptor activity [GO:0015026],
immunoglobulin binding [GO:0019865],
enzyme binding [GO:0019899],
protein kinase binding [GO:0019901],
signaling receptor activity [GO:0038023],
interleukin-16 binding [GO:0042011],
interleukin-16 receptor activity [GO:0042012],
MHC class II protein binding [GO:0042289],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
protein tyrosine kinase binding [GO:1990782],
receptor binding [GO:0005102],

Cellular Component:
early endosome [GO:0005769],
endoplasmic reticulum lumen [GO:0005788],
endoplasmic reticulum membrane [GO:0005789],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
external side of plasma membrane [GO:0009897],
clathrin-coated vesicle membrane [GO:0030665],
T cell receptor complex [GO:0042101],
membrane raft [GO:0045121],
cell surface [GO:0009986],
membrane [GO:0016020],
integral component of membrane [GO:0016021],