CD36

CD36 molecule

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Saos-2, Li-Fraumeni Human YES
29974107 BJ, MRC-5 Human NO
31534052 Kidney Mouse YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
positive regulation of cell-matrix adhesion [GO:0001954],
toll-like receptor signaling pathway [GO:0002224],
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479],
production of molecular mediator involved in inflammatory response [GO:0002532],
platelet degranulation [GO:0002576],
MyD88-dependent toll-like receptor signaling pathway [GO:0002755],
lipid metabolic process [GO:0006629],
fatty acid metabolic process [GO:0006631],
receptor-mediated endocytosis [GO:0006898],
phagocytosis, recognition [GO:0006910],
phagocytosis, engulfment [GO:0006911],
cell adhesion [GO:0007155],
positive regulation of cytosolic calcium ion concentration [GO:0007204],
nitric oxide mediated signal transduction [GO:0007263],
blood coagulation [GO:0007596],
positive regulation of gene expression [GO:0010628],
positive regulation of macrophage derived foam cell differentiation [GO:0010744],
positive regulation of cholesterol storage [GO:0010886],
positive regulation of cell death [GO:0010942],
long-chain fatty acid transport [GO:0015909],
short-chain fatty acid transport [GO:0015912],
regulation of lipid metabolic process [GO:0019216],
cytokine-mediated signaling pathway [GO:0019221],
lipid storage [GO:0019915],
cGMP-mediated signaling [GO:0019934],
positive regulation of blood coagulation [GO:0030194],
intestinal cholesterol absorption [GO:0030299],
cholesterol transport [GO:0030301],
receptor internalization [GO:0031623],
regulation of lipopolysaccharide-mediated signaling pathway [GO:0031664],
positive regulation of interleukin-12 production [GO:0032735],
positive regulation of interleukin-6 production [GO:0032755],
positive regulation of tumor necrosis factor production [GO:0032760],
response to lipid [GO:0033993],
regulation of toll-like receptor signaling pathway [GO:0034121],
triglyceride transport [GO:0034197],
plasma lipoprotein particle clearance [GO:0034381],
low-density lipoprotein particle clearance [GO:0034383],
response to stilbenoid [GO:0035634],
toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124],
negative regulation of protein import into nucleus [GO:0042308],
lipoprotein transport [GO:0042953],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
regulation of protein complex assembly [GO:0043254],
apoptotic cell clearance [GO:0043277],
neutrophil degranulation [GO:0043312],
long-chain fatty acid import [GO:0044539],
positive regulation of nitric oxide biosynthetic process [GO:0045429],
interleukin-1 beta secretion [GO:0050702],
positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731],
defense response to Gram-positive bacterium [GO:0050830],
intestinal absorption [GO:0050892],
sensory perception of taste [GO:0050909],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
low-density lipoprotein particle mediated signaling [GO:0055096],
positive regulation of phagocytosis, engulfment [GO:0060100],
positive regulation of macrophage cytokine production [GO:0060907],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
cholesterol import [GO:0070508],
response to fatty acid [GO:0070542],
response to linoleic acid [GO:0070543],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to lipoteichoic acid [GO:0071223],
cellular response to low-density lipoprotein particle stimulus [GO:0071404],
cellular response to hydroperoxide [GO:0071447],
cellular response to diacyl bacterial lipopeptide [GO:0071726],
energy homeostasis [GO:0097009],
regulation of action potential [GO:0098900],
positive regulation of NLRP3 inflammasome complex assembly [GO:1900227],
positive regulation of reactive oxygen species biosynthetic process [GO:1903428],
cellular response to beta-amyloid [GO:1904646],
amyloid fibril formation [GO:1990000],
lipid transport across blood brain barrier [GO:1990379],
regulation of removal of superoxide radicals [GO:2000121],
positive regulation of blood microparticle formation [GO:2000334],
long-chain fatty acid metabolic process [GO:0001676],
negative regulation of systemic arterial blood pressure [GO:0003085],
triglyceride metabolic process [GO:0006641],
immune response [GO:0006955],
cell surface receptor signaling pathway [GO:0007166],
response to mechanical stimulus [GO:0009612],
response to bacterium [GO:0009617],
negative regulation of gene expression [GO:0010629],
fatty acid transport [GO:0015908],
negative regulation of angiogenesis [GO:0016525],
fatty acid oxidation [GO:0019395],
glucose homeostasis [GO:0042593],
eating behavior [GO:0042755],
positive regulation of MAPK cascade [GO:0043410],
regulation of transcription from RNA polymerase II promoter in response to oxidative stress [GO:0043619],
positive regulation of cytokine secretion [GO:0050715],
positive regulation of phagocytosis [GO:0050766],
cellular response to bacterial lipopeptide [GO:0071221],
positive regulation of triglyceride metabolic process [GO:0090208],
positive regulation of reactive oxygen species metabolic process [GO:2000379],

Molecular Function:
beta-amyloid binding [GO:0001540],
low-density lipoprotein receptor activity [GO:0005041],
scavenger receptor activity [GO:0005044],
long-chain fatty acid transporter activity [GO:0005324],
protein binding [GO:0005515],
high-density lipoprotein particle binding [GO:0008035],
lipid binding [GO:0008289],
short-chain fatty acid uptake transporter activity [GO:0015636],
low-density lipoprotein particle binding [GO:0030169],
Toll-like receptor binding [GO:0035325],
macromolecular complex binding [GO:0044877],
transforming growth factor beta binding [GO:0050431],
thrombospondin receptor activity [GO:0070053],
lipoteichoic acid receptor activity [GO:0070892],
lipoprotein particle binding [GO:0071813],
oleic acid binding [GO:0070538],

Cellular Component:
extracellular space [GO:0005615],
Golgi apparatus [GO:0005794],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
external side of plasma membrane [GO:0009897],
cell surface [GO:0009986],
membrane [GO:0016020],
apical plasma membrane [GO:0016324],
endocytic vesicle membrane [GO:0030666],
platelet alpha granule membrane [GO:0031092],
brush border membrane [GO:0031526],
specific granule membrane [GO:0035579],
receptor complex [GO:0043235],
membrane raft [GO:0045121],
phagocytic vesicle [GO:0045335],
cell periphery [GO:0071944],
mitochondrion [GO:0005739],
endoplasmic reticulum [GO:0005783],
caveola [GO:0005901],
integral component of membrane [GO:0016021],
macromolecular complex [GO:0032991],
sarcolemma [GO:0042383],
intracellular membrane-bounded organelle [GO:0043231],
apical part of cell [GO:0045177],