ADAM metallopeptidase domain 19

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
placenta development [GO:0001890],
membrane protein ectodomain proteolysis [GO:0006509],
positive regulation of gene expression [GO:0010628],
extracellular matrix organization [GO:0030198],
positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049],
proteolysis [GO:0006508],
heart development [GO:0007507],

Molecular Function:
metalloendopeptidase activity [GO:0004222],
protein binding [GO:0005515],
SH3 domain binding [GO:0017124],
metal ion binding [GO:0046872],
peptidase activity [GO:0008233],
metallopeptidase activity [GO:0008237],
hydrolase activity [GO:0016787],

Cellular Component:
nucleus [GO:0005634],
Golgi apparatus [GO:0005794],
plasma membrane [GO:0005886],
integral component of membrane [GO:0016021],
external side of plasma membrane [GO:0009897],
membrane [GO:0016020],