CD2AP

CD2 associated protein

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31148378 MRC-5 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
actin filament organization [GO:0007015],
cell cycle [GO:0007049],
vesicle organization [GO:0016050],
cell migration [GO:0016477],
negative regulation of transforming growth factor beta1 production [GO:0032911],
proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161],
regulation of receptor-mediated endocytosis [GO:0048259],
positive regulation of protein secretion [GO:0050714],
negative regulation of small GTPase mediated signal transduction [GO:0051058],
cell division [GO:0051301],
cell-cell adhesion [GO:0098609],
positive regulation of protein localization to nucleus [GO:1900182],
regulation of actin cytoskeleton reorganization [GO:2000249],
substrate-dependent cell migration, cell extension [GO:0006930],
signal transduction [GO:0007165],
macromolecular complex assembly [GO:0065003],

Molecular Function:
vascular endothelial growth factor receptor binding [GO:0005172],
protein binding [GO:0005515],
beta-catenin binding [GO:0008013],
protein C-terminus binding [GO:0008022],
SH3 domain binding [GO:0017124],
identical protein binding [GO:0042802],
macromolecular complex binding [GO:0044877],
cadherin binding [GO:0045296],
structural constituent of cytoskeleton [GO:0005200],

Cellular Component:
fibrillar center [GO:0001650],
ruffle [GO:0001726],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
plasma membrane [GO:0005886],
cell-cell junction [GO:0005911],
cell cortex [GO:0005938],
cell junction [GO:0030054],
endocytic vesicle [GO:0030139],
cell leading edge [GO:0031252],
filamentous actin [GO:0031941],
macromolecular complex [GO:0032991],
cell projection [GO:0042995],
perinuclear region of cytoplasm [GO:0048471],
actin cytoskeleton [GO:0015629],
extracellular exosome [GO:0070062],