CCR7

C-C motif chemokine receptor 7

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES
30988157 IMR-90 Human YES

GO terms:

Biological Process:
establishment of T cell polarity [GO:0001768],
positive regulation of cell-matrix adhesion [GO:0001954],
dendritic cell chemotaxis [GO:0002407],
myeloid dendritic cell chemotaxis [GO:0002408],
positive regulation of dendritic cell antigen processing and presentation [GO:0002606],
positive regulation of hypersensitivity [GO:0002885],
positive regulation of humoral immune response [GO:0002922],
chemotaxis [GO:0006935],
inflammatory response [GO:0006954],
immune response [GO:0006955],
G-protein coupled receptor signaling pathway [GO:0007186],
positive regulation of cytosolic calcium ion concentration [GO:0007204],
calcium-mediated signaling [GO:0019722],
positive regulation of actin filament polymerization [GO:0030838],
positive regulation of pseudopodium assembly [GO:0031274],
ruffle organization [GO:0031529],
response to lipopolysaccharide [GO:0032496],
regulation of interferon-gamma production [GO:0032649],
positive regulation of interleukin-12 production [GO:0032735],
response to prostaglandin E [GO:0034695],
chemokine (C-C motif) ligand 19 signaling pathway [GO:0038115],
chemokine (C-C motif) ligand 21 signaling pathway [GO:0038116],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552],
negative thymic T cell selection [GO:0045060],
positive regulation of cell adhesion [GO:0045785],
positive regulation of protein kinase activity [GO:0045860],
positive regulation of JNK cascade [GO:0046330],
homeostasis of number of cells [GO:0048872],
regulation of interleukin-1 beta secretion [GO:0050706],
positive regulation of T cell receptor signaling pathway [GO:0050862],
release of sequestered calcium ion into cytosol [GO:0051209],
positive regulation of filopodium assembly [GO:0051491],
positive regulation of protein kinase B signaling [GO:0051897],
cell chemotaxis [GO:0060326],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
cellular response to cytokine stimulus [GO:0071345],
response to nitric oxide [GO:0071731],
interleukin-12 secretion [GO:0072610],
positive regulation of neutrophil chemotaxis [GO:0090023],
activation of GTPase activity [GO:0090630],
lymphocyte migration into lymph node [GO:0097022],
mature conventional dendritic cell differentiation [GO:0097029],
positive regulation of cell motility [GO:2000147],
positive regulation of dendritic cell chemotaxis [GO:2000510],
positive regulation of immunological synapse formation [GO:2000522],
positive regulation of T cell costimulation [GO:2000525],
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation [GO:2000526],
regulation of dendritic cell dendrite assembly [GO:2000547],
negative regulation of dendritic cell apoptotic process [GO:2000669],
negative regulation of interleukin-12 secretion [GO:2001183],
lymphocyte chemotaxis across high endothelial venule [GO:0002518],
regulation of tolerance induction to self antigen [GO:0002649],
signal transduction [GO:0007165],
activation of JUN kinase activity [GO:0007257],
positive regulation of macrophage chemotaxis [GO:0010759],
positive regulation of T cell chemotaxis [GO:0010820],
actin cytoskeleton organization [GO:0030036],
positive regulation of tumor necrosis factor production [GO:0032760],
positive regulation of T cell proliferation [GO:0042102],
positive regulation of GTPase activity [GO:0043547],
positive regulation of T-helper 1 cell differentiation [GO:0045627],
positive regulation of receptor-mediated endocytosis [GO:0048260],
lymph node development [GO:0048535],
positive regulation of interleukin-1 beta secretion [GO:0050718],
positive regulation of phagocytosis [GO:0050766],
negative regulation of leukocyte apoptotic process [GO:2000107],
positive regulation of thymocyte migration [GO:2000412],

Molecular Function:
G-protein coupled receptor activity [GO:0004930],
C-C chemokine receptor activity [GO:0016493],
chemokine binding [GO:0019956],
C-C chemokine binding [GO:0019957],
chemokine (C-C motif) ligand 19 binding [GO:0035757],
chemokine (C-C motif) ligand 21 binding [GO:0035758],
C-C motif chemokine 19 receptor activity [GO:0038117],
C-C motif chemokine 21 receptor activity [GO:0038121],
chemokine receptor activity [GO:0004950],
protein binding [GO:0005515],

Cellular Component:
mitochondrion [GO:0005739],
plasma membrane [GO:0005886],
external side of plasma membrane [GO:0009897],
cell surface [GO:0009986],
integral component of membrane [GO:0016021],
membrane [GO:0016020],