ADAM17

ADAM metallopeptidase domain 17

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
25077560 PC3, MCF7, IMR-90 Human NO
31184599 WI-38, IMR-90, HCA-2 Human YES
31983656 IPSC-MSC Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31208977 CAKI-1 Human NO
31983656 MSC Human YES

GO terms:

Biological Process:
response to hypoxia [GO:0001666],
positive regulation of protein phosphorylation [GO:0001934],
neutrophil mediated immunity [GO:0002446],
germinal center formation [GO:0002467],
positive regulation of leukocyte chemotaxis [GO:0002690],
proteolysis [GO:0006508],
membrane protein ectodomain proteolysis [GO:0006509],
cell adhesion [GO:0007155],
epidermal growth factor receptor signaling pathway [GO:0007173],
Notch signaling pathway [GO:0007219],
Notch receptor processing [GO:0007220],
positive regulation of cell proliferation [GO:0008284],
positive regulation of T cell chemotaxis [GO:0010820],
B cell differentiation [GO:0030183],
positive regulation of cell growth [GO:0030307],
positive regulation of cell migration [GO:0030335],
positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511],
negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512],
membrane protein intracellular domain proteolysis [GO:0031293],
response to lipopolysaccharide [GO:0032496],
positive regulation of chemokine production [GO:0032722],
regulation of mast cell apoptotic process [GO:0033025],
T cell differentiation in thymus [GO:0033077],
tumor necrosis factor-mediated signaling pathway [GO:0033209],
cell adhesion mediated by integrin [GO:0033627],
wound healing, spreading of epidermal cells [GO:0035313],
receptor transactivation [GO:0035624],
response to drug [GO:0042493],
positive regulation of blood vessel endothelial cell migration [GO:0043536],
positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737],
positive regulation of epidermal growth factor-activated receptor activity [GO:0045741],
spleen development [GO:0048536],
cell motility [GO:0048870],
defense response to Gram-positive bacterium [GO:0050830],
PMA-inducible membrane protein ectodomain proteolysis [GO:0051088],
positive regulation of cellular component movement [GO:0051272],
cellular response to high density lipoprotein particle stimulus [GO:0071403],
positive regulation of G1/S transition of mitotic cell cycle [GO:1900087],
positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265],
positive regulation of vascular endothelial cell proliferation [GO:1905564],
production of molecular mediator involved in inflammatory response [GO:0002532],
positive regulation of neuron projection development [GO:0010976],
negative regulation of neuron projection development [GO:0010977],
positive regulation of apoptotic process [GO:0043065],
negative regulation of apoptotic process [GO:0043066],
regulation of axon regeneration [GO:0048679],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
regulation of neuron migration [GO:2001222],

Molecular Function:
endopeptidase activity [GO:0004175],
metalloendopeptidase activity [GO:0004222],
Notch binding [GO:0005112],
interleukin-6 receptor binding [GO:0005138],
integrin binding [GO:0005178],
protein binding [GO:0005515],
peptidase activity [GO:0008233],
metallopeptidase activity [GO:0008237],
SH3 domain binding [GO:0017124],
PDZ domain binding [GO:0030165],
metal ion binding [GO:0046872],
serine-type endopeptidase activity [GO:0004252],
hydrolase activity [GO:0016787],

Cellular Component:
cytoplasm [GO:0005737],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
cell-cell junction [GO:0005911],
focal adhesion [GO:0005925],
cell surface [GO:0009986],
actin cytoskeleton [GO:0015629],
membrane [GO:0016020],
apical plasma membrane [GO:0016324],
ruffle membrane [GO:0032587],
membrane raft [GO:0045121],
extracellular region [GO:0005576],
integral component of membrane [GO:0016021],
cytoplasmic vesicle [GO:0031410],
apical part of cell [GO:0045177],