ADAM metallopeptidase domain 15

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
angiogenesis [GO:0001525],
negative regulation of cell-matrix adhesion [GO:0001953],
immune response to tumor cell [GO:0002418],
proteolysis [GO:0006508],
apoptotic process [GO:0006915],
cell-matrix adhesion [GO:0007160],
integrin-mediated signaling pathway [GO:0007229],
male gonad development [GO:0008584],
extracellular matrix disassembly [GO:0022617],
extracellular matrix organization [GO:0030198],
negative regulation of cell growth [GO:0030308],
negative regulation of cell migration [GO:0030336],
collagen catabolic process [GO:0030574],
tissue regeneration [GO:0042246],
innate immune response [GO:0045087],
cardiac epithelial to mesenchymal transition [GO:0060317],
negative regulation of receptor binding [GO:1900121],
cellular response to phorbol 13-acetate 12-myristate [GO:1904628],
response to hypobaric hypoxia [GO:1990910],
cell adhesion [GO:0007155],

Molecular Function:
metalloendopeptidase activity [GO:0004222],
integrin binding [GO:0005178],
protein binding [GO:0005515],
metallopeptidase activity [GO:0008237],
SH3 domain binding [GO:0017124],
metal ion binding [GO:0046872],
peptidase activity [GO:0008233],
hydrolase activity [GO:0016787],

Cellular Component:
acrosomal vesicle [GO:0001669],
plasma membrane [GO:0005886],
adherens junction [GO:0005912],
cell surface [GO:0009986],
integral component of membrane [GO:0016021],
motile cilium [GO:0031514],
extracellular exosome [GO:0070062],
extracellular space [GO:0005615],
cilium [GO:0005929],
membrane [GO:0016020],
cell junction [GO:0030054],
cytoplasmic vesicle [GO:0031410],
cell projection [GO:0042995],