ADAM metallopeptidase domain 12

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31895587 Spleen Mouse NO

GO terms:

Biological Process:
proteolysis [GO:0006508],
cell adhesion [GO:0007155],
myoblast fusion [GO:0007520],
extracellular matrix organization [GO:0030198],
positive regulation of angiogenesis [GO:0045766],

Molecular Function:
metalloendopeptidase activity [GO:0004222],
protein binding [GO:0005515],
metallopeptidase activity [GO:0008237],
SH3 domain binding [GO:0017124],
metal ion binding [GO:0046872],
peptidase activity [GO:0008233],
hydrolase activity [GO:0016787],

Cellular Component:
extracellular region [GO:0005576],
nucleoplasm [GO:0005654],
plasma membrane [GO:0005886],
integral component of membrane [GO:0016021],
membrane [GO:0016020],