ADAM10

ADAM metallopeptidase domain 10

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
26071561 J3, U266, ARP, ARK, OPM-2, LP1 Bone marrow Human NO
31945054 IMR-90 Human YES
31983656 MSC Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28437250 bEnd.3 murine brain endothelial cell line Mouse NO
32109515 Brain Mouse NO

GO terms:

Biological Process:
in utero embryonic development [GO:0001701],
protein phosphorylation [GO:0006468],
membrane protein ectodomain proteolysis [GO:0006509],
negative regulation of cell adhesion [GO:0007162],
Notch signaling pathway [GO:0007219],
integrin-mediated signaling pathway [GO:0007229],
cell-cell signaling [GO:0007267],
spermatogenesis [GO:0007283],
positive regulation of cell proliferation [GO:0008284],
regulation of Notch signaling pathway [GO:0008593],
positive regulation of T cell chemotaxis [GO:0010820],
protein processing [GO:0016485],
extracellular matrix disassembly [GO:0022617],
positive regulation of cell growth [GO:0030307],
positive regulation of cell migration [GO:0030335],
beta-amyloid formation [GO:0034205],
adherens junction organization [GO:0034332],
response to tumor necrosis factor [GO:0034612],
Notch receptor processing, ligand-dependent [GO:0035333],
monocyte activation [GO:0042117],
amyloid precursor protein catabolic process [GO:0042987],
positive regulation of apoptotic process [GO:0043065],
neutrophil degranulation [GO:0043312],
post-translational protein modification [GO:0043687],
cellular protein metabolic process [GO:0044267],
pore complex assembly [GO:0046931],
PMA-inducible membrane protein ectodomain proteolysis [GO:0051088],
constitutive protein ectodomain proteolysis [GO:0051089],
regulation of dendritic spine morphogenesis [GO:0061001],
cochlea development [GO:0090102],
response to antineoplastic agent [GO:0097327],
regulation of vasculature development [GO:1901342],
toxin transport [GO:1901998],
proteolysis [GO:0006508],
nucleocytoplasmic transport [GO:0006913],
Notch receptor processing [GO:0007220],

Molecular Function:
endopeptidase activity [GO:0004175],
metalloendopeptidase activity [GO:0004222],
receptor binding [GO:0005102],
integrin binding [GO:0005178],
protein binding [GO:0005515],
metallopeptidase activity [GO:0008237],
SH3 domain binding [GO:0017124],
protein kinase binding [GO:0019901],
protein homodimerization activity [GO:0042803],
metal ion binding [GO:0046872],
metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902945],
peptidase activity [GO:0008233],
hydrolase activity [GO:0016787],
SH2 domain binding [GO:0042169],

Cellular Component:
Golgi membrane [GO:0000139],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
endoplasmic reticulum lumen [GO:0005788],
Golgi apparatus [GO:0005794],
Golgi-associated vesicle [GO:0005798],
trans-Golgi network [GO:0005802],
plasma membrane [GO:0005886],
adherens junction [GO:0005912],
focal adhesion [GO:0005925],
synaptic vesicle [GO:0008021],
cell surface [GO:0009986],
postsynaptic density [GO:0014069],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
clathrin-coated vesicle [GO:0030136],
axon [GO:0030424],
specific granule membrane [GO:0035579],
neuronal cell body [GO:0043025],
dendritic spine [GO:0043197],
intracellular membrane-bounded organelle [GO:0043231],
postsynaptic membrane [GO:0045211],
pore complex [GO:0046930],
extracellular exosome [GO:0070062],
tertiary granule membrane [GO:0070821],
perinuclear endoplasmic reticulum [GO:0097038],
synaptic membrane [GO:0097060],
tetraspanin-enriched microdomain [GO:0097197],
glutamatergic synapse [GO:0098978],
cell junction [GO:0030054],
dendrite [GO:0030425],
cytoplasmic vesicle [GO:0031410],
cell projection [GO:0042995],
postsynapse [GO:0098794],