CCN2

cellular communication network factor 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
22684333 MDA-MB-231, Primary fibroblast derived from foreskin Human NO
27752926 BJ Skin Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, primary fibroblasts derived from skin Human YES
32570219 Primary fibroblasts derived from skin Human, mouse NO
32973510 Kidney Mouse NO

GO terms:

Biological Process:
cartilage condensation [GO:0001502],
ossification [GO:0001503],
angiogenesis [GO:0001525],
tissue homeostasis [GO:0001894],
transcription initiation from RNA polymerase II promoter [GO:0006367],
cell adhesion [GO:0007155],
cell-matrix adhesion [GO:0007160],
signal transduction [GO:0007165],
integrin-mediated signaling pathway [GO:0007229],
aging [GO:0007568],
positive regulation of cell proliferation [GO:0008284],
fibroblast growth factor receptor signaling pathway [GO:0008543],
epidermis development [GO:0008544],
response to wounding [GO:0009611],
response to glucose [GO:0009749],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
cell migration [GO:0016477],
cell differentiation [GO:0030154],
lung development [GO:0030324],
regulation of chondrocyte differentiation [GO:0032330],
response to estradiol [GO:0032355],
positive regulation of collagen biosynthetic process [GO:0032967],
response to anoxia [GO:0034059],
intracellular signal transduction [GO:0035556],
chondrocyte proliferation [GO:0035988],
response to amino acid [GO:0043200],
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280],
response to peptide hormone [GO:0043434],
positive regulation of cell differentiation [GO:0045597],
positive regulation of JNK cascade [GO:0046330],
positive regulation of cell activation [GO:0050867],
response to mineralocorticoid [GO:0051385],
positive regulation of stress fiber assembly [GO:0051496],
cytosolic calcium ion transport [GO:0060401],
positive regulation of cardiac muscle contraction [GO:0060452],
negative regulation of cell death [GO:0060548],
extracellular matrix constituent secretion [GO:0070278],
positive regulation of G0 to G1 transition [GO:0070318],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
response to fatty acid [GO:0070542],
DNA biosynthetic process [GO:0071897],
reactive oxygen species metabolic process [GO:0072593],
positive regulation of protein phosphorylation [GO:0001934],
positive regulation of cell death [GO:0010942],
connective tissue development [GO:0061448],

Molecular Function:
fibronectin binding [GO:0001968],
integrin binding [GO:0005178],
protein binding [GO:0005515],
insulin-like growth factor binding [GO:0005520],
protein C-terminus binding [GO:0008022],
growth factor activity [GO:0008083],
heparin binding [GO:0008201],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
cis-Golgi network [GO:0005801],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
cell cortex [GO:0005938],
extracellular matrix [GO:0031012],
perinuclear region of cytoplasm [GO:0048471],